| Identification | Back Directory | [Name]
COH34 | [CAS]
906439-72-3 | [Synonyms]
COH34
1-Naphthalenecarboxaldehyde, 2-hydroxy-, S-(4-methylphenyl)thiooxime | [Molecular Formula]
C18H15NOS | [MOL File]
906439-72-3.mol | [Molecular Weight]
293.38 |
| Chemical Properties | Back Directory | [Boiling point ]
495.5±55.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.07±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1]. | [in vivo]
COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1]. | [References]
[1] Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340. DOI:10.1126/sciadv.aav4340 |
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| Company Name: |
cjbscvictory
|
| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
|