| Identification | More | [Name]
3,4-Dimethoxybenzoic acid | [CAS]
93-07-2 | [Synonyms]
3,4-DIMETHOXYBENZOIC ACID
AKOS 220-15
AKOS BBS-00003717
DIMETHYLPROTOCATECHUIC ACID
PROTOCATECHUIC ACID DIMETHYL ETHER
RARECHEM AL BO 0042
VERATRIC ACID
3,4-dimethoxy-benzoicaci
3,4-Dimethylprotocatechuic acid
3,4-dimethylprotocatechuicacid
Veratrumenoic acid
3,4-DIMETHOXYBENZOIC ACID, 99+%
3,4-DIMETHOXYENZIOC ACID
3,4-DimethoxbenzoicAcid99%
3,4-Dimethoxybenzoic
Benzoic acid, 3,4-dimethoxy-
VERATRIC ACID(RG)
reratric acid
3,4-DIMETHOXY BENZOIC ACID (VERATRIC ACID) ,99+%
3,4-DIMETHOXYBENZOIC ACID (VERATRIC ACID) | [EINECS(EC#)]
202-215-7 | [Molecular Formula]
C9H10O4 | [MDL Number]
MFCD00002500 | [Molecular Weight]
182.17 | [MOL File]
93-07-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly yellow powder | [Melting point ]
179-182 °C(lit.)
| [Boiling point ]
275.56°C (rough estimate) | [density ]
1.2481 (rough estimate) | [refractive index ]
1.4500 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
0.5g/l | [form ]
Crystalline Powder | [pka]
4.35±0.10(Predicted) | [color ]
Almost white to beige or reddish | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
slightly soluble | [Merck ]
14,9953 | [BRN ]
518285 | [Henry's Law Constant]
1.1×105 mol/(m3Pa) at 25℃, Abraham and Jr. (2019) | [Cosmetics Ingredients Functions]
HAIR CONDITIONING | [InChI]
1S/C9H10O4/c1-12-7-4-3-6(9(10)11)5-8(7)13-2/h3-5H,1-2H3,(H,10,11) | [InChIKey]
DAUAQNGYDSHRET-UHFFFAOYSA-N | [SMILES]
COc1ccc(cc1OC)C(O)=O | [LogP]
1.610 | [CAS DataBase Reference]
93-07-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzoic acid, 3,4-dimethoxy-(93-07-2) | [EPA Substance Registry System]
93-07-2(EPA Substance) |
| Hazard Information | Back Directory | [Description]
Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits and has antioxidant and anti-inflammatory activities. It also acts as a protective agent against hypertension-associated cardiovascular remodeling. Veratric acid reduces upregulated COX-2 expression and levels of PGE2 and IL-6 after UVB irradiation. This compound could be reduced to veratrine aldehyde, and alcohol was performed with enzyme extracts from a wood-degrading basidiomycete, Polystictus (Trametes) versicolor[1].
| [Chemical Properties]
white to slightly yellow powder | [Uses]
3,4-Dimethoxybenzoic acid is a derivative of Protocatechuic Acid.3,4-Dimethoxybenzoic acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.
| [Uses]
Derivative of Protocatechuic Acid, and is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds. | [Definition]
ChEBI: A member of the class of benzoic acids that is benzoic acid substituted by methoxy groups at positions 2 and 3. | [Synthesis Reference(s)]
Chemical and Pharmaceutical Bulletin, 26, p. 299, 1978 DOI: 10.1248/cpb.26.299
Tetrahedron Letters, 43, p. 4985, 2002 DOI: 10.1016/S0040-4039(02)00929-2 | [Synthesis]
Veratric acid is prepared via a two-step synthesis starting with the methylation of acetovanillon using dimethylsulphate in alkaline media to obtain 3,4-dimethoxy acetophenone, followed by an oxidation based on the haloform reaction with sodium hypochlorite in alkaline media[2]. | [in vitro]
Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation, and HDAC3 expression in RAW264.7 cells.
Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis.
Veratric acid reduces upregulated COX-2 expression and levels of PGE2, and IL-6 after UVB irradiation.
| [storage]
Store at -20°C | [Purification Methods]
Crystallise the acid from Et2O, H2O or aqueous acetic acid. It has m 180-181o after sublimation at 80o/1mm. [Beilstein 10 H 393, 10 I 188, 10 II 261, 10 III 1404, 10 IV 1406.] | [References]
[1] Gross, Georg G. “From lignins to tannins: Forty years of enzyme studies on the biosynthesis of phenolic compounds.” Phytochemistry 69 18 (2008): Pages 3018-3031.
|
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|