930-62-1

52726-31-5

930-62-1

The general procedure for the synthesis of 2,4-dimethylimidazole from the compound (CAS:52726-31-5) was as follows: in a 16 mL reaction flask equipped with a PTFE/silicone septum and a nitrogen bubbler device, N-benzylbenzimidazole (208.1 mg, 1.0 mmol), dry Pd/C catalyst (10 wt%, 20 mg), and THF ( 5 mL). Triethylsilane (320 μL, 2.0 mmol) was slowly added to the reaction mixture under nitrogen protection, followed by continuous stirring for 14 h at room temperature. Upon completion of the reaction, the reaction mixture was filtered using a 0.45 μm PTFE syringe filter and the filtrate was concentrated under reduced pressure to remove the solvent. The resulting residue was purified by column chromatography (eluent: 0 to 10% methanol/dichloromethane gradient) to afford the target product benzimidazole as a colorless solid (117.6 mg, 0.996 mmol, 99% yield). It is worth noting that the reaction typically suffers from an induction period of 5 to 30 min, which can be observed as reaction initiation by the apparent release of gas from the reaction mixture (i.e., the bubbling phenomenon). In addition, the use of a dry Pd/C catalyst is essential for this reaction, with wet Pd/C leading to a significant reduction in the reaction yield or no reaction at all.