| Identification | Back Directory | [Name]
FiVe1 | [CAS]
932359-76-7 | [Synonyms]
FiVe1
8-Chloro-4-(4-(3-chlorophenyl)piperazin-1-yl)cinnoline
FiVe1 8-Chloro-4-(4-(3-chlorophenyl)piperazin-1-yl)cinnoline | [Molecular Formula]
C18H16Cl2N4 | [MOL File]
932359-76-7.mol | [Molecular Weight]
359.25 |
| Chemical Properties | Back Directory | [Boiling point ]
570.2±60.0 °C(Predicted) | [density ]
1.374±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
5.56±0.10(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Description]
FiVe1 is a novel vimentin (VIM) ligand, selectively and irreversibly inhibiting the growth of mesenchymally transformed breast cancer cells and soft tissue sarcomas of diverse histological subtypes. | [Uses]
FiVe1 is a potent vimentin (VIM; the intermediate filament and mesenchymal marker) inhibitor[1]. FiVe1 promotes VIM disorganization and phosphorylation during metaphase, leading to mitotic catastrophe, multinucleation, and the loss of stemness.?FiVe1 selectively and irreversibly inhibits the growth of multiple FOXC2-expressing breast cancer cell lines (HMLER cells (IC50:?267 nM); FOXC2-HMLER cells (IC50:?447 nM). FiVe1 inhibits the migration of mesenchymally transformed cells[1]. | [References]
[1] Michael J Bollong, et al. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. DOI:10.1073/pnas.1716009114 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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