| Identification | Back Directory | [Name]
Propargyl-PEG3-NH2 | [CAS]
932741-19-0 | [Synonyms]
Alkyne-PEG3-amine
2‐(2‐(2‐(prop‐2‐yn‐1‐yloxy)ethoxy)ethoxy)ethanamine
Ethanamine, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethan-1-amine | [Molecular Formula]
C9H17NO3 | [MDL Number]
MFCD20720810 | [MOL File]
932741-19-0.mol | [Molecular Weight]
187.24 |
| Chemical Properties | Back Directory | [Boiling point ]
267.4±25.0 °C(Predicted) | [density ]
1.019±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow | [Appearance]
colorlessoryellowish liquid | [InChI]
InChI=1S/C9H17NO3/c1-2-4-11-6-8-13-9-7-12-5-3-10/h1H,3-10H2 | [InChIKey]
MREICTHRFCQNJR-UHFFFAOYSA-N | [SMILES]
C(N)COCCOCCOCC#C |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG3-amine is a PEG linker that is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group reacts with azides in copper catalyzed azide-alkyne Click Chemistry. | [Uses]
Propargyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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