| Identification | Back Directory | [Name]
Propargyl-PEG3-t-butyl ester | [CAS]
1374658-84-0 | [Synonyms]
1374658-84-0
Propargyl-PEG3-Boc
Propargyl-PEG3-COOtBu
Alkyne-PEG3-CH2CH2COOtBu
PROPARGYL-PEG3-CH2CH2COOTBU
Propargyl-PEG3-t-butyl ester
Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C14H24O5 | [MDL Number]
MFCD22201522 | [MOL File]
1374658-84-0.mol | [Molecular Weight]
272.34 |
| Chemical Properties | Back Directory | [Boiling point ]
337.2±27.0 °C(Predicted) | [density ]
1.023±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, stored under nitrogen | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG3-t-butyl ester consists of an alkyne group and a t-butyl ester group. The alkyne groupreacts with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Propargyl-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Henan Alfachem Co.,Ltd.
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www.chemicalbook.com/supplier/14555231/ |
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Nextpeptide Inc
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http://www.nextpeptide.com/ |
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