| Identification | More | [Name]
7-Methylindole | [CAS]
933-67-5 | [Synonyms]
7-METHYINDOLE
7-METHYL-1H-INDOLE
7-METHYLINDOLE
7-Methylindol
Indole, 7-methyl-
1H-Indole, 7-methyl-
7-Methylindole,98%
7-Metlylindole
7-METHYL-1-NAPHTHOL | [EINECS(EC#)]
213-270-1 | [Molecular Formula]
C9H9N | [MDL Number]
MFCD00005684 | [Molecular Weight]
131.17 | [MOL File]
933-67-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly beige shiny flakes | [Melting point ]
80-84 °C (lit.) | [Boiling point ]
266 °C (lit.) | [density ]
1.0202 | [refractive index ]
1.6070 (estimate) | [Fp ]
266°C | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Crystalline | [pka]
17.30±0.30(Predicted) | [color ]
Off-White to Pale Beige | [Water Solubility ]
negligible | [Sensitive ]
Light Sensitive | [Detection Methods]
GC,NMR | [BRN ]
111088 | [InChI]
1S/C9H9N/c1-7-3-2-4-8-5-6-10-9(7)8/h2-6,10H,1H3 | [InChIKey]
KGWPHCDTOLQQEP-UHFFFAOYSA-N | [SMILES]
Cc1cccc2cc[nH]c12 | [LogP]
2.560 | [CAS DataBase Reference]
933-67-5(CAS DataBase Reference) | [NIST Chemistry Reference]
1H-Indole, 7-methyl-(933-67-5) | [Storage Precautions]
Light sensitive |
| Questions And Answer | Back Directory | [Synthesis]
Weigh 10 mmol of 2-methylaniline and 0.2 mmol of AlCl3 into a reaction flask, dissolve them in 100 mL of tetrahydrofuran, and add 30 mmol of ethylene oxide to the reaction flask at 0 °C. Maintain 0 °C and stir the reaction for 10 h. After separation and purification, N-hydroxyethyl-2-methylaniline (yield 83.1%) is obtained. Weigh 5 mmol of N-hydroxyethyl-2-methylaniline and 7.5 mmol of 2-methylaniline into a reaction flask, dissolve them in 200 mL of acetonitrile, add Sn/activated carbon supported catalyst, and stop the reaction after TLC detection of complete reaction of N-hydroxyethyl-2-methylaniline. After separation and purification, 7-methylindole was obtained (yield 64.3%). | [Uses]
7-Methylindole is a reactant in the synthesis of α-amino amides that are found in a variety of biological-active compounds. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R36:Irritating to the eyes.
R21/22:Harmful in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [F ]
13 | [Hazard Note ]
Light Sensitive/Irritant | [HS Code ]
29309090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
|
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