| Identification | Back Directory | [Name]
t-Boc-N-Amido-PEG2-Azide | [CAS]
950683-55-3 | [Synonyms]
N3-PEG2-NH-BOC
Boc-NH-PEG(2)-N3
Azido-PEG2-NHBoc
Boc-N-Amido-PEG2-N3
BocNH-PEG2-CH2CH2N3
Boc-N-Amido-PEG2-Azide
t-Boc-N-Amido-PEG2-Azide
Boc-N-Amido-PEG2-C2-azide
t-Boc-N-Amido-PEG2-Azide 98%
1-(Boc-amino)-3,6-dioxa-8-octaneazide
1-(Boc-amino)-3,6-dioxa-8-octaneazide≥ 98% (HPLC)
tert-butyl {2-[2-(2-azidoethoxy)ethoxy]ethyl}carbamate
{2-[2-(2-azidoethoxy)ethoxy]ethyl}carbamic acid tert-butyl ester
Carbamicacid,N-[2-[2-(2-azidoethoxy)ethoxy]ethyl]-,1,1-dimethylethylester | [Molecular Formula]
C11H22N4O4 | [MDL Number]
MFCD23380094 | [MOL File]
950683-55-3.mol | [Molecular Weight]
274.32 |
| Hazard Information | Back Directory | [Description]
t-Boc-N-Amido-PEG2-azide is a PEG linker, which can react with alkyne, BCN, DBCO via Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Chemical Properties]
Light yellow oil | [Uses]
Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-N-Amido-PEG2-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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