| Identification | Back Directory | [Name]
t-Boc-N-Amido-PEG4-Azide | [CAS]
940951-99-5 | [Synonyms]
BocNH-P5-N3
Boc-NH-PEG4-N3
N3-PEG4-NH-BOC
Boc-NH-PEG4-azide
BocNH-PEG4-CH2CH2N3
Azido-PEG4-Boc Amine
Boc-N-Amido-PEG4-Azide
t-Boc-N-Amido-PEG4-Azide
tert-Butyl (14-azido-3,6,9,12-tetraoxatetradecyl)carbamate | [Molecular Formula]
C15H30N4O6 | [MDL Number]
MFCD28015765 | [MOL File]
940951-99-5.mol | [Molecular Weight]
362.43 |
| Hazard Information | Back Directory | [Description]
t-Boc-N-Amido-PEG4-azide is a N-Boc protected PEG reagent. It can react with alkyne, BCN, DBCO via Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Uses]
Boc-NH-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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