| Identification | Back Directory | [Name]
t-Boc-Aminoxy-PEG3-Azide | [CAS]
1235514-15-4 | [Synonyms]
Boc-Aminoxy-PEG3-N3
Boc-Aminooxy-PEG3-Azide
t-Boc-Aminoxy-PEG3-Azide
t-Boc-Aminooxy-PEG3-azide
tert-butyl 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxycarbamate | [Molecular Formula]
C13H26N4O6 | [MDL Number]
MFCD28950781 | [MOL File]
1235514-15-4.mol | [Molecular Weight]
334.37 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG3-azide is a click chemistry reagent containing a t-Boc-aminooxy group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The protected aminooxy can be deprotected under mild acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Boc-Aminooxy-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
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