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95635-55-5

95635-55-5 Structure

95635-55-5 Structure
IdentificationMore
[Name]

Ranolazine
[CAS]

95635-55-5
[Synonyms]

n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
RANOLAZINE
1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethy]piperazine
CVT 303
Ranexa
Renexa
RS 43285-003
1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-
[Molecular Formula]

C24H33N3O4
[MDL Number]

MFCD00864690
[Molecular Weight]

427.54
[MOL File]

95635-55-5.mol
Chemical PropertiesBack Directory
[Appearance]

White Solid
[Usage]

Anti-ischemic agent which modulates myocardial metabolism. Antianginal
[CAS DataBase Reference]

95635-55-5(CAS DataBase Reference)
Questions And AnswerBack Directory
[Description]

Ranolazine ([(+)N-(2,6-dimethylphenyl)-4(2-hydroxy-3-(2-methoxyphenoxy)-propyl)-1-piperazine acetamide dihydrochloride]) is an active piperazine derivative that was patented in 1986 and is available in an oral and intravenous form. Ranolazine is evidenced with anti-ischemic/antianginal properties in patients with chronic angina without clinically significant changes in heart rate or blood pressure.  
Ranolazine is used for the treatment of angina (chronic chest pain). Researches show it also has potential use in cardiovascular conditions such as heart failure, acute and chronic myocardial ischemia, certain types of cardiac sodium channel gene mutations, and ventricular and supraventricular arrhythmias.
[References]

[1] Bernard R. Chaitman, Ranolazine for the Treatment of Chronic Angina and Potential Use in Other Cardiovascular Conditions, New Drugs and Technologies, 2006, vol. 113, 2462-2472
[2] Bernard R. Chaitman, Sandra L. Skettino, John O. Parker, Peter Hanley, Jaroslav Meluzin, Jerzy Kuch and Carl J. Pepine, Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina, Journal of the American College of Cardiology, 2004, vol. 43, 1375-1382
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

95635-55-5(sigmaaldrich)
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