| Identification | More | [Name]
Guaiacol glycidyl ether | [CAS]
2210-74-4 | [Synonyms]
[(2-methoxyphenoxy)methyl]oxirane
3-(O-METHOXYPHENOXY)-1,2-EPOXYPROPANE
GUAIACOL GLYCIDYL ETHER
O-METHOXY PHENYL CYCLOXYPROPYL ETHER
1,2-epoxy-3-(o-methoxyphenoxy)-propan
1,2-epoxy-3-(o-methoxyphenoxy)propane
3-(2-Methoxphenoxy)-1,2-epoxypropane
guajacol-glycidaether
[(o-methoxyphenoxy)methyl]oxirane
1-(2-Mthoxyphenoxy)methyl oxirane
RZ-3
N-2,6-dimethylphenyl-2-chloro acetamide
RZ-1
1,2-Epoxy-3-(2-Methoxyphenoxy)Propane
3-(Dimethoxyphenoxy)-1,2-Propylene Epoxide
1-[(2-methoxyphenoxy)methyl]oxirane oppure guaiacol glycidyl ether
2-((2-METHOXYPHENOXY)METHYL)OXIRANE:95+%
1-(2-Methoxyphenoxy)-2,3-Epoxy Propane
1-(2,3-Epoxypropoxy)-2-methoxybenzene
2-[(2-Methoxyphenoxy)methyl]oxirane | [EINECS(EC#)]
218-644-8 | [Molecular Formula]
C10H12O3 | [MDL Number]
MFCD00190158 | [Molecular Weight]
180.2 | [MOL File]
2210-74-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
33-36°C | [Boiling point ]
152-158℃ | [density ]
1.142±0.06 g/cm3(Predicted) | [RTECS ]
TZ3550000 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Chloroform, Methanol | [form ]
Solid | [color ]
Off-white | [Water Solubility ]
4.21g/L at 20℃ | [Usage]
Ranolazine intermediate | [Major Application]
pharmaceutical | [InChI]
InChI=1S/C10H12O3/c1-11-9-4-2-3-5-10(9)13-7-8-6-12-8/h2-5,8H,6-7H2,1H3 | [InChIKey]
RJNVSQLNEALZLC-UHFFFAOYSA-N | [SMILES]
O1CC1COC1=CC=CC=C1OC | [LogP]
1.54 at 25℃ | [CAS DataBase Reference]
2210-74-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [HS Code ]
29109000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Skin Irrit. 2
Skin Sens. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
Ranolazine intermediate | [Flammability and Explosibility]
Nonflammable | [Synthesis]
To a round-bottomed flask was added 2.5 L of water followed by 80 g of sodium hydroxide and stirred until completely dissolved. Next, 500 g of guaiacol and 1.12 kg of 1-chloro-2,3-epoxypropane were added and the reaction was continuously stirred at 25-35°C for 5-6 hours. After completion of the reaction, the organic layer was separated. To the separated obtained epichlorohydrin layer was added 160 g of sodium hydroxide dissolved in 2.5 L of water and stirring was continued at 25-30 °C for 3-4 hours. The organic layer was again separated and the organic layer was washed with 150 g of sodium hydroxide dissolved in 1.5 L of water. Subsequently, the product layer was distilled at 90°C and 600-700 mmHg under vacuum to recover excess epichlorohydrin, resulting in 650-680 g of oily product. To this crude product was added 3.0 L of isopropanol, cooled to 0 °C and filtered to give 1-(2-methoxyphenoxy)-2,3-epoxypropane (3). Yield: 80%; purity >98%. | [References]
[1] Organic Process Research and Development, 2012, vol. 16, # 10, p. 1660 - 1664
[2] Medicinal Chemistry Research, 2004, vol. 13, # 8-9, p. 631 - 642
[3] Synthetic Communications, 1994, vol. 24, # 6, p. 833 - 838
[4] Tetrahedron, 2006, vol. 62, # 47, p. 10968 - 10979
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 26, p. 6641 - 6644 |
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