| Identification | Back Directory | [Name]
11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2 | [CAS]
958759-75-6 | [Synonyms]
SAAKCJFTIGHOEX-WQXLGBCHSA-N
11-DEOXY-11-METHYLENE-15-KETO PROSTAGLANDIN D2
9ALPHA,HYDROXY-11-METHYLENE-15-OXO-PROSTA-5Z,13E-DIEN-1-OIC ACID
Prosta-5,13-dien-1-oic acid, 9-hydroxy-11-methylene-15-oxo-, (5Z,9α,13E)- | [Molecular Formula]
C21H32O4 | [MDL Number]
MFCD05863942 | [MOL File]
958759-75-6.mol | [Molecular Weight]
348.48 |
| Hazard Information | Back Directory | [Description]
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor.1 However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2.2,3 This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2.4 11-deoxy-11-methylene-15-keto PGD2 was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2. | [Definition]
ChEBI: 11-Deoxy-11-methylene-15-keto-PGD2 is a prostanoid. | [References]
1. Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor J. Biol. Chem. 270(32),18910-18916(1995).
2. Gervais, F.G., Cruz, R., Chateauneuf, A., et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP J. Allergy Clin. Immunol. 108(6),982-988(2002).
3. Monneret, G., Gravel, S., Diamond, M., et al. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor Blood 98(6),1942-1948(2001).
4. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193(2),255-261(2001). |
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