| Identification | More | [Name]
CYTIDINE 5'-DIPHOSPHOCHOLINE | [CAS]
987-78-0 | [Synonyms]
CDP-CHOLINE
CITICOLINE
CYTIDINE 5'-DIPHOSPHOCHOLINE
CYTIDINE DIPHOSPHATE CHOLINE
cdp-cholin
cdp-colina
cereb
choline,hydroxide,5’-esterwithcytidine5’-(trihydrogenpyrophosphate),inne
choline5’-cytidinediphosphate
cholinecytidinediphosphate
citicholine
citidindifosfatodecolina
citidoline
colite
cytidindiphosphocholin
cytidine5’-(cholinediphosphate)
cytidine5’-diphosphatecholine
cytidinecholinediphosphate
cytidinediphosphatecholineester
cytidinediphosphatecholinester | [EINECS(EC#)]
213-580-7 | [Molecular Formula]
C14H26N4O11P2 | [MDL Number]
MFCD00868097 | [Molecular Weight]
488.32 | [MOL File]
987-78-0.mol |
| Questions And Answer | Back Directory | [Description]
Citicoline whose chemical name choline cytosine nucleoside-5'-diphosphate monosodium salt, is a precursor for lecithin biosynthesis, and when brain function declines, the content of lecithin in brain tissue is significantly reduced. |
| Chemical Properties | Back Directory | [Melting point ]
>185°C (dec.) | [alpha ]
D25 +19.0° (c = 0.86 in H2O) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Water (Sparingly) | [form ]
Solid | [pka]
4.4(at 25℃) | [color ]
White | [Stability:]
Moisture Sensitive | [InChIKey]
RZZPDXZPRHQOCG-APGYLPRWNA-N | [SMILES]
O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C=CC(N)=NC1=O)O |&1:1,2,3,21,r| | [LogP]
-7.070 (est) | [CAS DataBase Reference]
987-78-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Originator]
Nicholin,Cyanamid,Italy,1971 | [Uses]
antidepressant, 5HT uptake inhibitor | [Definition]
ChEBI: CDP-choline is a member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a human metabolite, a psychotropic drug, a neuroprotective agent, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a member of phosphocholines and a member of nucleotide-(amino alcohol)s. It is functionally related to a CDP. It is a conjugate base of a CDP-choline(1+). | [Manufacturing Process]
A 250 ml conical flask containing 30 ml of a reaction liquor (pH 7.0) having a
composition of 7.38 mg/ml of disodium salt of CMP (cytidine-5'-
monophosphate), 24 mg/ml of choline, 10 mg/ml of glucose, 100 mg/ml of
acetone-dried cells of Brevibacterium ammoniagenes ATCC 6872, 11.6 mg/ml
of monopotassium phosphate, 20 mg/ml of dipotassium phosphate and 2.96
mg/ml of magnesium sulfate, (MgSO4·7H2O), was subjected to culturing at
30°C for 4 hours. Cytidine diphosphate choline was formed and accumulated
at a concentration of 3.8 mg/ml in the culture liquor.
The pH of 1.2 liters of filtrate containing 3.8 mg/ml of cytidine diphosphate
choline, obtained by removing solid matters from the culturing liquor, was
adjusted to a pH of 8.5 with a 0.5 N KOH solution. The filtrate was passed
through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic
acid type). After washing the resin with water, a formic acid solution was
passed through the column with gradual increase in the concentration of
formic acid (until 0.04 N max.). A fraction of cytidine diphosphate choline was
collected by elution according to the so-called gradient elution method and
absorbed onto carbon powders. Then, elution was effected with acetone, and
the eluate was concentrated and dried. 1.3 g of cytidine diphosphate choline
powders were obtained. | [Therapeutic Function]
Cerebral circulation stimulant |
|
|