| Identification | More | [Name]
Cloquintocet-mexyl | [CAS]
99607-70-2 | [Synonyms]
CLOQUINTOCET-1-METHYLHEXYL ESTER
CLOQUINTOCET-MEXYL
CLOQUINTOCET-MEXYL PESTANAL, 250 MG
cloquitocet_mexyl
Acetic acid, (5-chloro-8-quinolinyl)oxy-, 1-methylhexyl ester
1-Methylhexyl (5-chloroquinolin-8-yloxy)acetate | [EINECS(EC#)]
619-447-3 | [Molecular Formula]
C18H22ClNO3 | [MDL Number]
MFCD01632329 | [Molecular Weight]
335.83 | [MOL File]
99607-70-2.mol |
| Chemical Properties | Back Directory | [Appearance]
beige solid | [Melting point ]
69° | [Boiling point ]
448.4±30.0 °C(Predicted) | [density ]
1.163±0.06 g/cm3(Predicted) | [vapor pressure ]
0-54.4Pa at 25-185.9℃ | [storage temp. ]
0-6°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) | [form ]
neat | [pka]
1.94±0.29(Predicted) | [color ]
White to Off-White | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Merck ]
14,2401 | [LogP]
5.2-5.24 at 25℃ and pH5-9.1 | [Surface tension]
56.8-57.2mN/m at 590μg/L and 20℃ | [Dissociation constant]
3.55 at 20℃ | [CAS DataBase Reference]
99607-70-2(CAS DataBase Reference) | [EPA Substance Registry System]
Cloquintocet-mexyl (99607-70-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R43:May cause sensitization by skin contact. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
UN 3077 | [WGK Germany ]
2 | [RTECS ]
AG1265000 | [HS Code ]
2933.49.3000 | [Toxicity]
LD50 in rats (mg/kg): >2000 orally; >2000 dermally; LC50 (4 hr) in rats: >935 mg/m3 by inhalation (Amrein) |
| Hazard Information | Back Directory | [Description]
Cloquintocet-mexyl is a colourless crystalline herbicide safener. It is categorized as Class III toxin. | [Chemical Properties]
beige solid | [Uses]
Cloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the 1980s and the patent has expired. | [Definition]
ChEBI: Heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate is a member of the class of quinolines that is quinoline which is substituted by a chloro group at position 5 and by a 2-[(heptan-2-yl)oxy]-2-oxoethoxy group at position 8. It is an aromatic ether, an organochlorine compound, a member of quinolines and a carboxylic ester. | [Agricultural Uses]
Cloquintocet-mexyl is a safener that can be used in conjunction with various herbicides to reduce phytotoxicity to crops. Though effective as a safener, the manufacture, storage, and use of cloquintocet-mexyl containing products can present challenges owing to its sensitivity to water and its low melting temperature (i.e., 61-69° C. for technical material). When products containing cloquintocet-mexyl are prepared, stored, or used in the presence of water, cloquin tocet-mexyl can undergo hydrolysis to form cloquintocet acid, and/or form a needle-shaped, crystalline hydrate that can, lead to clogged spray nozzles during spray applications and/or possibly increased levels of crop phytotoxicity. | [Carcinogenicity]
In accordance with the EPA Proposed EPA Weight-of-the-Evidence Categories, August 1999, the HIARC classified cloquintocet-mexyl as "not likely to be a human carcinogen." Carcinogenicity studies in rats and mice did not show increased incidence of spontaneous tumor formation. With negative mutagenic test battery, it is suggested that cloquintocet-mexyl (CGA 185072) is not likely to be a human carcinogen. | [Metabolism]
Metabolism studies in rats indicated that approximately 40% of the administered dose of cloquintocet-mexyl was absorbed through the gastrointestinal tract and subsequently excreted via the urine. Fecal excretion accounted for approximately 60% of the administered dose. The chemical was rapidly eliminated (more than 80% of the administered dose) via feces and urine within 48 hours post-dosing. Sex, dosing regime, and dose levels had little effect on the excretion pattern. Excretion patterns were similar between the biliary cannulated and non-cannulated animals indicating that there was no enterohepatic circulation of the chemical. Three days after administration, tissue radioactivity accounted for less than 0.3% of the administered dose (or was non-detectable) and was not detectable in the expired air. At day three post-dosing, most tissue residues of radioactivity were below the limit of detection. The major metabolic pathway of cloquintocet-mexyl was ester hydrolysis to yield 5-chloro-8-quinolinoxy acetic acid, the major metabolite in the fecal and urinary pools. | [storage]
Store at -20°C | [Toxicity evaluation]
Cloquintocet-mexyl has a low order of acute oral, dermal, and inhalation toxicity. It is slightly irritating to the eyes and non-irritating to the skin. Cloquintocet-mexyl is a skin sensitizer. The chemical is not genotoxic and is not a reproductive and developmental toxicant. There is no evidence of neurotoxicity in the available studies. Cloquintocet-mexyl is classified as “not likely to be a human carcinogen.” The main metabolite for cloquintocet-mexyl is 5-chloro-8-quin-linoxyacetic acid, and testing on the metabolite is part of the toxicology database for cloquintocet-mexyl. |
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