120-46-7
120-46-7 结构式
基本信息
1,3-二苯基-1,3-丙二酮
1,3-二苯基丙二酮
ω-苯甲酰基苯乙酮
二苯甲酰甲烷
二苯甲醯甲烷
二苯甲酰基甲烷, 98+%
1,3-diphenylpropane-1,3-dione
DBM
DIBENZOYLMETHANE
,3-Diphenyl-propane-1,3-dione
1,3-Diphenyl-1,3-propanediamine
1,3-diphenyl-3-propanedione
1,3-Diphenylpropanedione
2-Benzoylacetophenone
3-Propanedione,1,3-diphenyl-1
arenzu dk 2
-Benzoylacetophenone
-Benzoylace-tophenone
Dibenzoylmethan
hodiastab 83
-Hydroxy-chalkone
karenzudk2
omega-Benzoylacetophenone
Phenyl phenacyl ketone
Phenyl-hydroxystyrylketone
物理化学性质
安全数据
应用领域
常见问题列表
NaOH催化法：该方法使用NaOH作为催化剂，苯作为溶剂，苯乙酮与苯甲酸甲酯在加热条件下进行反应。反应结束后，通过蒸馏、萃取、结晶等步骤得到产品二苯甲酰基甲烷。然而，该方法存在产品收率低、色泽差等缺点。 EtOH/EtONa催化法：以EtOH/EtONa为催化剂和溶剂，苯甲酸乙酯和苯乙酮为原料进行反应。尽管该方法制备过程相对简单，但产品二苯甲酰基甲烷的色泽同样不佳，且EtOH/EtONa溶液配制困难，后处理存在危险。
二苯甲酰甲烷是甘草中的次要成分，可激活 Nrf2 并预防各种癌症和氧化损伤。Dibenzoylmethane 是姜黄素的类似物，会引起 Keap1 解离和 Nrf2 的核易位。
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h.
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells.
Dibenzoylmethane does not show significant cytotoxicity.
Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice.
Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice.