13392-18-2
中文名称
非诺特罗
英文名称
Fenoterol
CAS
13392-18-2
分子式
C17H21NO4
MDL 编号
MFCD00242675
分子量
303.35
MOL 文件
13392-18-2.mol
更新日期
2024/04/12 14:37:00
13392-18-2 结构式
基本信息
中文别名
5-[1-羟基-2-[[2-(4-羟基苯基)-1-甲基乙基]氨基]乙基]-1,3-苯二酚非诺特罗
英文别名
1-(3,5-dihydroxyphenyl)-1-hydroxy-2-[(4-hydroxyphenyl)isopropylamino]ethane5-[1-hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-1,3-benzenediol
AURORA KA-7877
FENOTEROL
1-(p-hydroxyphenyl)-2-((beta-hydroxy-beta-(3’,5’-dihydroxyphenyl))ethyl)amin
1,3-benzenediol,5-(1-hydroxy-2-((2-(4-hydroxyphenyl)-1-methylethyl)amino)eth
3,5-dihydroxy-alpha-(((p-hydroxy-alpha-methylphenethyl)amino)methyl)benzyla
benzylalcohol,3,5-dihydroxy-alpha-(((p-hydroxy-alpha-methylphenethyl)amino)me
lcohol
opropane
1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-[1-(4-hydroxyphenyl)isopropyl]aminoethane
1-(3,5-Dihydroxyphenyl)-2-(p-hydroxy-α-methylphenethylamino)ethanol
1-(3,5-Dihydroxyphenyl)-2-[[1-(4-hydroxybenzyl)ethyl]amino]ethanol
1,3-Benzenediol, 5-[1-hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-
3,5-Dihydroxy-α-[p-hydroxy-α-methylphenethylamino]methylbenzyl alcohol
Benzyl alcohol, 3,5-dihydroxy-α-[[(p-hydroxy-α-methylphenethyl)amino]methyl]- (8CI)
Phenoterol
Th 1165
3,5-Dihydroxy-α-[[(4-hydroxy-α-methylphenethyl)amino]methyl]benzyl alcohol
所属类别
原料药：平喘药物理化学性质
熔点181-183°C
沸点566.0±45.0 °C(Predicted)
密度1.289±0.06 g/cm3(Predicted)
储存条件-20°C储存
酸度系数(pKa)pKa 8.5 (Uncertain);10.0 (Uncertain)
常见问题列表
生物活性
Fenoterol (Phenoterol) 是β2 adrenoreceptor激动剂，具有支气管扩张活性。靶点
| Target | Value |
|
β2 adrenoreceptor
() |
体外研究
Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.
Western Blot Analysis
| Cell Line: | THP-1 cells stimulated with AICAR |
| Concentration: | 1 μM |
| Incubation Time: | Pre-incubated 30 minutes |
| Result: | Significantly downregulated the elevated phosphorylation levels of AMPK. |
体内研究
Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.
| Animal Model: | Male C57BL/6J mice (6 weeks old) with neuropathy |
| Dosage: | 0.7 mg/kg |
| Administration: | Intraperitoneal injection; twice a day; for 3 weeks |
| Result: | Alleviated neuropathic allodynia during chronic treatment. |