17193-40-7
中文名称
(S)-4-硝基苯基丙氨酸甲酯盐酸盐
英文名称
L-4-Nitrophenylalanine methyl ester hydrochloride
CAS
17193-40-7
分子式
C10H13ClN2O4
MDL 编号
MFCD00135754
分子量
260.67
MOL 文件
17193-40-7.mol
更新日期
2024/08/05 10:18:13
17193-40-7 结构式
基本信息
中文别名
4-硝基-L-苯丙氨酸甲酯盐酸盐(S)-4-硝基苯基丙氨酸甲酯盐酸盐
(S)-4-硝基苯丙氨酸甲酯 盐酸盐,97%
英文别名
4-NITRO-L-PHENYLALANINE METHYL ESTER HYDROCHLORIDEH-PHE(4-NO2)-OME HCL
H-PHE(P-NO2)-OME HCL
H-P-NITRO-PHE-OME HCL
L-4-NITROPHENYLALANINE METHYL ESTER HCL
METHYL 4-NITRO-L-PHENYLALANINATE HYDROCHLORIDE
METHYL (S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIATE HYDROCHLORIDE
P-NITRO-L-PHENYLALANINE METHYL ESTER HCL
P-NITRO-L-PHENYLALANINE METHYL ESTER HYDROCHLORIDE
P-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
P-NITRO-PHENYLALANINE-OME HCL
(S)-(+)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
(S)-4-NITROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
(S)-ALFA-AMINO-4-NITRO BENZENEPROPANOIC ACID METHYL ESTER HYDROCHLORIDE
3-(4-Nitrophenyl)-L-alanine methylester hydrochloride
4-Nitro-L-Phenylalanine Methyl Ester HCl
(S)-Methyl-4-Nitro Phenyl Alaninate hydrochloride
4-Nitro-L-Phenylalanine methyl ester monohydrochloride
4-NO2-Phe-oMe.HCL
L-4-Nitrophenylalanine methyl ester hydrochloride
所属类别
生物化工：丙氨酸类衍生物物理化学性质
熔点210-214 °C
储存条件2-8°C
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
形态powder to crystal
颜色White to Light yellow
旋光度 (Optical Rotation)20.9° (c=1.0 g/100ml, ETOH)
BRN5176380
制备方法
方法1
67-56-1
949-99-5
17193-40-7
在0℃条件下，将亚硫酰氯（1.03 mL，14.2 mmol）缓慢滴加到(S)-2-氨基-3-(4-硝基苯基)丙酸（0.995 g，4.73 mmol）溶于10 mL甲醇的悬浮液中。滴加完毕后，将反应体系逐渐升温至室温。随后，将反应混合物加热回流反应过夜。反应完成后，通过减压蒸馏浓缩反应液。粗产物采用甲醇/乙酸乙酯混合溶剂进行重结晶纯化，最终得到(S)-4-硝基苯基丙氨酸甲酯盐酸盐1.012 g，收率为95%。
参考文献：
[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 22, p. 3686 - 3700
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 18, p. 3566 - 3580
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5407 - 5413
[4] Chemistry - A European Journal, 2017, vol. 23, # 24, p. 5824 - 5829
[5] New Journal of Chemistry, 2017, vol. 41, # 23, p. 14723 - 14729