2058-46-0
2058-46-0 结构式
基本信息
盐酸土霉素
盐酸地霉素
盐酸氧四环素
酸土霉素
土霉素盐酸
5-hydroxytetracycline hydrochloride
AQUACYCLINE
BIO-MYCIN
GEOMYCIN
OTC
OXYTETRACYCLINE HCL
OXYTETRACYCLINE HYDROCHLORIDE
TETRAMYCIN
TOXINAL
10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-monohydrochloride
2-naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,
5alpha,5aalpha,6beta,12aalpha)]-aalph
6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,monohydrochloride,[4s-(4alpha,4
biosolvomycin
engemycin
hydrocyclin
liquamycininjectable
mepatar
nsc9169
物理化学性质
安全数据
应用领域
常见问题列表
1、由链球菌、巴氏杆菌、丹毒杆菌、肺炎球菌等引起的链球菌病、猪肺疫、萎缩性鼻炎、水肿病、母畜产后感染及各种呼吸道感染。
2、由原虫引起的畜禽血虫病（附红细胞体感染）、弓形体病、牛羊鞭虫病、 猪旋毛虫病等。
3、由支原体引起的猪气喘病（支原体肺炎）、禽霉形体肺炎（慢性呼吸道病）等。
4、用于水产的败血症、肠炎、烂尾烂鳃病、白头白嘴病、郑州弧菌病、鳗赤鳍病等。
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HSV-1
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Bacterial
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Human Endogenous Metabolite
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Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.
The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in
Morone chrysops x M. saxatilis
, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter.
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.