231957-54-3

中文名称 MIV-150

英文名称 MIV-150

CAS 231957-54-3

分子式 C19H17FN4O3

分子量 368.36

MOL 文件 231957-54-3.mol

231957-54-3 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T16081

英文别名

PC 815
MIV-150
MIV150,MIV 150
1-(5-cyanopyridin-2-yl)-3-[(1S,2S)-2-(6-fluoro-2-hydroxy-3-

物理化学性质

储存条件-20°C储存

溶解度DMF: 30 mg/mL; DMSO: 30 mg/mL; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL; Ethanol: 0.25 mg/mL

形态结晶固体

常见问题列表

生物活性

MIV-150 是 NNTR 的一个抑制剂，可以抑制 HIV-1 和 HIV-2 感染，其对 HIV-1/HIV-2 的 EC50 值为 <1 nM。

靶点

HIV-1

<1 nM (EC ₅₀ )

HIV-2

<1 nM (EC ₅₀ )

体外研究

The activity of MIV-150 to protect target cells from infection is assayed using a syncytial assay. The EC ₅₀ of MIV-150 against HIV-1MN in CEM.SS cells is below 1 nM. These data are in agreement with the findings of Medivir. MIV-150 effectively inactivated free virus with an EC ₅₀ of 0.004 μg/mL (or 0.01 μM). It is demonstrated MIV-150 is highly effective against HIV and that the drug blocks viruses that are resistant to other marketed HIV antiretrovirals such as Nevirapine, Delavirdine, and Efavirenz. In addition, resistance to MIV-150 develops more slowly than to other anti-HIV drugs tested. For example, in vitro studies demonstrate that resistance development in the presence of nevirapine and delavirdine takes only 4 to 5 weeks compared with 45 weeks in the presence of MIV-150.