314054-00-7
中文名称
N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
英文名称
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
CAS
314054-00-7
分子式
C11H7IN2O4
分子量
358.09
MOL 文件
314054-00-7.mol
更新日期
2025/05/13 19:27:07
314054-00-7 结构式
基本信息
中文别名
化合物C-176N-(4-碘苯基)-5-硝基-2-呋喃甲酰胺
英文别名
C-176STING inhibitor 1
C-176 STING inhibitor
N-(4-iodophenyl)-5-nitro-2-furamide
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-
所属类别
生物化工：抑制剂物理化学性质
沸点361.2±37.0 °C(Predicted)
密度1.935±0.06 g/cm3(Predicted)
储存条件2-8°C(protect from light)
储存条件Keep in dark place,Sealed in dry,2-8°C
溶解度溶于DMSO（高达25mg/ml）
酸度系数(pKa)11.14±0.70(Predicted)
形态固体
颜色棕色或黄色
稳定性可在-20°C的DMSO中的溶液下储存长达3个月。
N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-112906 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 C-176 | 314054-00-7 | 5mg | 1000元 |
| 2025/02/08 | HY-112906 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 C-176 | 314054-00-7 | 10mM * 1mLin DMSO | 1100元 |
| 2025/02/08 | HY-112906 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 C-176 | 314054-00-7 | 10mg | 1400元 |
常见问题列表
生物活性
STING inhibitor C-176是一种有效的STING抑制剂。STING是细胞内DNA感应通路的主要信号分子。靶点
| Target | Value |
|
STING
() |
体外研究
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
体内研究
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1
−/−
mice.
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1
−/−
mice.
| Animal Model: | WT type mice. |
| Dosage: | 750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL). |
| Administration: | Intraperitoneally, once. |
| Result: | Significantly reduced Serum levels of type I IFNs and IL-6. |