481-74-3
481-74-3 结构式
基本信息
大黄酚
大黄酚(大黄根酸)
1,8-二羟基-3-甲基-蒽醌
大黄根酚
大黄根酸
驱虫豆酸
3-甲金黃異茜素
大黃根酚
大黃根酸
1,8-二羥-3-甲蒽醌
顯金黃酸
1,8-DIHYDROXY-3-METHYLANTHRAQUINONE
3-METHYLCHRYSAZIN
3-METHYLCHRYSAZINE
9,10-ANTHRACENEDIONE,1,8-DIHYDROXY-3-METHYL
CHRYSOPHANIC ACID
CHRYSOPHANOL
RHUBARB EXTRACT
1,8-dihydroxy-3-methyl-10-anthracenedione
1,8-Dihydroxy-3-methyl-9,10-anthraquinone
1,8-dihydroxy-3-methyl-anthraquinon
2-Methyl-4,5-dihydroxyanthraquinone
3-Methyl-1,8-dihydroxyanthraquinone
4,5-Dihydroxy-2-methylanthraquinone
Anthraquinone,1,8-dihydroxy-3-methyl-
c.i.75400
c.i.naturalyellow23
Chrysophansαure
turkeyrhubarb
CHRYSOPHANOL:9,10-ANTHRACENEDIONE,1,8-DIHYDROXY-3-METHYL
物理化学性质
安全数据
常见问题列表
| Target | Value |
| EGFR | |
| mTOR |
Chrysophanic acid (Chrysophanol)是EGFR/mTOR通路抑制剂。Chrysophanic acid (Chrysophanol)是一种天然的蒽醌化合物，在EGFR过表达的SNU-C5人类结肠癌细胞中具有抗癌活性。Chrysophanic acid (Chrysophanol)优先阻断SNU-C5细胞的增殖，但不会阻断EGFR表达水平较低的其他细胞系(HT7，HT29，KM12C，SW480，HCT116和SNU-C4)的增殖。Chrysophanic acid (Chrysophanol)处理SNU-C5细胞能够抑制EGFR中EGF诱导的磷酸化，并抑制下游信号分子，如AKT，细胞外信号调节激酶(ERK)以及哺乳动物类雷帕霉素靶蛋白(mTOR)/核糖体蛋白S6激酶(p70S6K)的活化。 在BGM(Buffalo green monkey)肾脏细胞中，Chrysophanic acid也能够抑制Ⅱ和Ⅲ型脊髓灰质炎病毒(小RNA病毒科)以及脊髓灰质炎病毒诱导的细胞病理效应。
Chrysophanol (CA) improves HFD-induced obesity in C57BL/6 Mice. The in vivo performance of Chrysophanol is performed in male C57BL/6J mice to determine the efficacy of administered Chrysophanol. Mice fed the HFD gained significantly more weight than those fed the standard diet mice. On the other hand, weight gain of Chrysophanol group is significantly less than with the untreated HFD. Mice in the HFD-group gained 23.92 ± 1.74 g of weight, while those in the Chrysophanol group gained 16.72±2 g of weight after 16 weeks.
知名试剂公司产品信息
Chrysophanic acid, 98%(481-74-3)