56-59-7
56-59-7 结构式
基本信息
2-苯丙氨酸-8-赖氨酸加压素
H-CYS-PHE-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2, CYS1,6, CYCLIC
[PHE2,LYS8]-VASOPRESSIN
2-L-Phenylalanine-8-L-lysine-vasopressin
N-[5-Amino-1-(carbamoylmethylcarbamoyl)pentyl]-1-[19-amino-13,16-dibenzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
2-(phenylalanine)-8-lyine vasopression
Octapressin
Phelypressin
PLV-2
M.W. 1040.22 C46H65N13O11S2
(2-L-Phenylalanine)-8-lysinevasopressin
2-(Phenylalanine)-8-lysine vasopressin
L-Cys(1)-L-Phe-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-L-Lys-Gly-NH2
物理化学性质
应用领域
不良反应和禁忌：用药后可有面色和皮肤苍白、尿意、腹痛、腹泻、脉搏减慢等症状；过量会恶心、呕吐。冠状动脉患者忌用，孕妇和老人慎用。
常见问题列表
Vasopressin 1
Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells.
Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure.
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors.