58691-88-6
中文名称
诺美孕酮
英文名称
Nomegestrol
CAS
58691-88-6
分子式
C21H28O3
分子量
328.45
MOL 文件
58691-88-6.mol
更新日期
2024/04/26 13:50:25
58691-88-6 结构式
基本信息
中文别名
诺美孕酮 英文别名
MonacoTherMex
Nomegestrel
Nomegestrol
NOMEGESTROL ACETATE
MELEGESTROL ACETATE
Nomegestrol USP/EP/BP
Nomegestrol###58691-88-6
17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
17-Hydroxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione
所属类别
原料药：雌激素及孕激素类药物理化学性质
沸点502.6±50.0 °C(Predicted)
密度1.17±0.1 g/cm3(Predicted)
储存条件Sealed in dry,2-8°C
溶解度Chloroform: soluble,DMSO: slightly soluble,Methanol: slightly soluble
酸度系数(pKa)12.99±0.60(Predicted)
形态固体
常见问题列表
生物活性
Nomegestrol 是一种有效的，可口服的孕酮，为选择性的孕酮受体 (progesterone receptor) 完全激动剂，对大鼠子宫孕酮受体的 Kd 值为 5.44 nM，具有很强的抗雌性激素活性，适度的抗雄性激素活性。靶点
Kd: 5.44 nM (Rat uterine progesterone receptor)
体外研究
Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a K d of 5.44 nM for rat uterine progesterone receptor. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity.