85643-19-2
中文名称
仙茅苷
英文名称
CURCULIGOSIDE
CAS
85643-19-2
分子式
C22H26O11
分子量
466.44
MOL 文件
85643-19-2.mol
更新日期
2024/04/25 09:54:50
85643-19-2 结构式
基本信息
中文别名
仙茅甙仙茅苷
仙茅苷(标准品)
仙茅苷(仙茅甙)
仙茅苷, 来源于仙茅
CURCULIGOSIDE 仙茅苷
英文别名
CURCULIGOSIDECurculigosideA
Curculigoside, 98%, from Curculigo orchioides Gaertn.
β-D-Glucopyranoside,2-[[(2,6-diMethoxybenzoyl)oxy]Methyl]-4-hydroxyphenyl
β-D-Glucopyranoside, 2-[[(2,6-dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl
2-[[(2,6-Dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl beta-D-Glucopyranoside
[5-Hydroxy-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl-2,6-dimethoxybenzoate
物理化学性质
外观性状白色颗粒结晶，易溶于甲醇，几乎不溶于乙醚，来源于仙茅。
熔点158-160 °C(Solv: methanol (67-56-1))
沸点734.9±60.0 °C(Predicted)
密度1.450±0.06 g/cm3(Predicted)
储存条件-20°C冷冻
溶解度少许溶于甲醇
酸度系数(pKa)9.70±0.20(Predicted)
形态固体
颜色米白色
常见问题列表
概述
仙茅苷有补肾壮阳、益精血、强健筋骨、行血消肿的功效。用于腎虚不足、阳痊遗精、虚瘦内伤、腰脊冷痛、寒虚冷泻、带下、小便频数等临床病症。生物活性
Curculigoside 是 C. orchioide 中的主要皂苷，具有显着的抗氧化，抗骨质疏松，抗抑郁和神经保护作用。
通过调节 JAK/STAT/NF-κB 信号传导途径，在体内和体外表现出显着的抗关节炎作用。靶点
JAK; STAT; NF-κB
体外研究
Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 µg/ml in MH7A cells. Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group.
Cell Viability Assay
| Cell Line: | MH7A cells |
| Concentration: | 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml |
| Incubation Time: | 72 hours |
| Result: | Had inhibitory effect on MH7A cells. |
Western Blot Analysis
| Cell Line: | MH7A cells |
| Concentration: | 4 μg/ml; 64 μg/ml |
| Incubation Time: | 24 hours |
| Result: | Downregulated JAK1, JAK3 and STAT3 protein expression. |