Salbutamol

Salbutamol 구조식 이미지
카스 번호:
34391-04-3
상품명:
Salbutamol
동의어(영문):
Salbutamol;r-albuterol;LEVALBUTEROL;Levalbutreol;(L)-ALBUTEROL;Levosalbutamol;R-SALBUTAMOL HCL;LEVALBUTEROL HCL;LEVOSALBUTEROLHCL;Levosalbutamol (Levalbuterol)
CBNumber:
CB0275903
분자식:
C13H21NO3
포뮬러 무게:
239.31
MOL 파일:
34391-04-3.mol

Salbutamol 속성

끓는 점
433.5±40.0 °C(Predicted)
밀도
1.152±0.06 g/cm3(Predicted)
산도 계수 (pKa)
9.99±0.31(Predicted)
InChI
InChI=1/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3/t12-/s3
InChIKey
NDAUXUAQIAJITI-PLAQIDKDNA-N
SMILES
C1(=CC=C(O)C(CO)=C1)[C@@H](O)CNC(C)(C)C |&1:9,r|
CAS 데이터베이스
34391-04-3(CAS DataBase Reference)

안전

위험품 표기 Xn
위험 카페고리 넘버 22
안전지침서 36

Salbutamol C화학적 특성, 용도, 생산

개요

Levalbuterol was launched in the US for the treatment or prevention of bronchospasm in patients with reversible obstructive airway disease. It is the single R-enantiomer version of racemic albuterol (salbutamol) marketed for more than 30 years as a mainstay in the treatment of asthma. The R-isomer can be obtained with an excellent optical purity by enantiomeric purification based on the separation of diastereomeric tartrates. This isomer retains solely the desired bronchodilating effect of the racemic mixture due to a potent agonistic effect on β2-adrenoceptors, with a lower incidence of β- mediated side effects such as pulse rate increase, tremor and decrease in blood glucose and potassium levels. A pivotal clinical trial with two doses of levalbuterol and racemic albuterol, given by nebulization, demonstrated a greater improvement in lung function for the pure enantiomer levalbuterol.

용도

(R)-Salbutamol is used in composition and methods to reduce beta-agonist-mediated tachyphylaxis.

Salbutamol 준비 용품 및 원자재

원자재

준비 용품


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