L(+)-2-氨基-4-膦酰基丁酸
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- CAS号:
- 23052-81-5
- 英文名:
- L-AP4
- 英文别名:
- GDF5;L-AP4;L-APB;SYNS2;CDMP1;GDF-5 human;GDF-5 mouse;BMP-14/ CDMP-1;BMP-14 (GDF-5/CDMP-1) human;2-ammonio-4-phosphonatobutanoate
- 中文名:
- L(+)-2-氨基-4-膦酰基丁酸
- 中文别名:
- (S)-2-氨基-4-膦酸丁酸;L(+)-2-氨基-4-膦酰基丁酸;L-AP4,III类MGLU激动剂;软骨衍生形态发生蛋白1/GDF 5抗体
- CBNumber:
- CB1141944
- 分子式:
- C4H10NO5P
- 分子量:
- 183.1
- MOL File:
- 23052-81-5.mol
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L(+)-2-氨基-4-膦酰基丁酸化学性质
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熔点:
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207-215 °C
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沸点:
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491.7±55.0 °C(Predicted)
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密度:
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1.628±0.06 g/cm3(Predicted)
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储存条件:
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0-6°C
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溶解度:
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H2O : 50 mg/mL (273.07 mM; Need ultrasonic)
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酸度系数(pKa):
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2.19±0.10(Predicted)
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形态:
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solid
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颜色:
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White
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水溶解性:
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Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
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敏感性:
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Light Sensitive
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CAS 数据库:
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23052-81-5(CAS DataBase Reference)
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L(+)-2-氨基-4-膦酰基丁酸性质、用途与生产工艺
L-APB 是一种有效的、代谢型谷氨酸受体 (mGluR) 的特异性激动剂，其对 mGlu4, mGlu8, mGlu6 和 mGlu7 受体的 EC50 值分别为 0.13, 0.29, 1.0, 249 μM。
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mGlu
4
0.13 μM (EC
50
)
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mGlu8
0.29 μM (EC
50
)
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mGlu
6
1.0 μM (EC
50
)
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mGlu7
249 μM (EC
50
)
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Paw withdrawal threshold in response to application of von Frey filaments before spinal nerve ligation is 22.6±2.4 g. The mechanical threshold decreases significantly (2.3±0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks. Intrathecal injection of 5 to 30 μg of L-APB significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration.
L(+)-2-氨基-4-膦酰基丁酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100781A | L(+)-2-氨基-4-膦酰基丁酸
L-AP4 | 23052-81-5 | 5mg | 2950元 |
| 2024/01/25 | HY-100781A | L-AP4 | | 10 mM * 1 mLin Water | 3245元 |
23052-81-5, L(+)-2-氨基-4-膦酰基丁酸 相关搜索:
- Glutamate
- Glutamate receptor
- 合成有机化合物配体
- mGluR4 and mGluR6 metabotropic glutamate receptor agonist.
- C4H10NO5P
- L-AP4,III类MGLU激动剂
- 软骨衍生形态发生蛋白1/GDF 5抗体
- (S)-2-氨基-4-膦酸丁酸
- L(+)-2-氨基-4-膦酰基丁酸
- 23052-81-5
- Butanoic acid, 2-amino-4-phosphono-, (2S)-
- (2S)-2-amino-4-phosphonobutanoic acid
- L-(+)-2-Amino-4-phosphonobutyric Acid - CAS 23052-81-5 - Calbiochem
- 2-ammonio-4-phosphonatobutanoate
- L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4)
- GDF5
- CDMP1
- Anti-GDF5 (C-terminal) antibody produced in rabbit
- GDF-5 mouse
- BMP-14/ CDMP-1
- BMP-14 (GDF-5/CDMP-1) human
- SYNS2
- GDF-5 human
- (S)-2-aMino-4-phosphonobutanoic acid
- L(+)-2-Amino-4-phosphonobutyric acid,97%
- L-APB
- (S)-4-Phosphono-2-aminobutyric acid
- (S)-4-Phosphono-2-aminobutanoic acid
- (2S)-2-Amino-4-phosphonobutyric acid
- L(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID 97%
- L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP4)
- L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID
- L(+)-2-AMINO-4-PHOSPHONOBUTANOIC ACID
- L-AP4