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L-AP4

L-AP4 구조식 이미지

카스 번호:: 23052-81-5

상품명:: L-AP4

동의어(영문):: GDF5;L-AP4;L-APB;SYNS2;CDMP1;GDF-5 human;GDF-5 mouse;BMP-14/ CDMP-1;BMP-14 (GDF-5/CDMP-1) human;2-ammonio-4-phosphonatobutanoate

CBNumber:: CB1141944

분자식:: C4H10NO5P

포뮬러 무게:: 183.1

MOL 파일:: 23052-81-5.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 94

L-AP4 속성

녹는점: 207-215 °C

끓는 점: 491.7±55.0 °C(Predicted)

밀도: 1.628±0.06 g/cm3(Predicted)

저장 조건: 0-6°C

용해도: H2O : 50 mg/mL (273.07 mM; Need ultrasonic)

산도 계수 (pKa): 2.19±0.10(Predicted)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 하얀색

수용성: 물에서는 5mM, 1eq에서는 100mM에 용해됩니다. NaOH

감도: Light Sensitive

CAS 데이터베이스: 23052-81-5(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
WGK 독일	3
RTECS 번호	ES7191700

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P304+P340	흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405	밀봉하여 저장하시오.

NFPA 704

	0
2		0

L-AP4 C화학적 특성, 용도, 생산

개요

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC₅₀ = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

화학적 성질

white to off-white crystalline powder

용도

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

생물학적 활성

Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

L-AP4 준비 용품 및 원자재

원자재

Glycine, N-[(1R,2R,5R)-2-hydroxy-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylidene]-, ethyl ester, [N(E)]- (S)-2-Amino-4-(diethoxyphosphoryl)butanoic acid D-AP4 DIETHYL VINYLPHOSPHONATE

준비 용품

L-AP4 공급 업체

글로벌( 94)공급 업체

공급자	전화	이메일	국가	제품 수	이점
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11605	64
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69

L-AP4 관련 검색:

1,2-디아미노프로판 DL-2-AMINO-4-PHOSPHONOBUTYRIC ACID (S)-2-Amino-2-methyl-4-phosphonobutanoic acid 4-PHOSPHONOBUTYRIC ACID 3-Aminopropylphosphonic acid L-AP4 ANTI-IMMUNOGLOBULIN A, HUMAN, AP ANTI-IGM MU-CHAIN, RAT AP CONJ ANTI-IGG H AND L CHAIN, GOAT AP CONJ ANTI-IGG, HUMAN AP CONJ ANTI-IGG GAMMA-CHAIN, HUMAN AP CONJ ANTI-IGG, MOUSE AP CONJ 16-AP ANTI-IGG H AND L CHAIN, HUMAN AP CONJ,ANTI-IGG(H+L), HUMAN AP CONJ ANTI-IGG H AND L CHAIN, RABBIT AP CONJ,ANTI-IGG(H+L), RABBIT AP CONJ ANTI-IMMUNOGLOBULIN G, BOVINE, F(AB')2, AP ANTI-IGG H AND L CHAIN, HORSE AP CONJ ANTI-IGG H AND L CHAIN, SHEEP AP CONJ