KC7F2
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- CAS号:
- 1357171-62-0
- 英文名:
- ML-228
- 英文别名:
- L-228;ML-228;CID-46742353;ML228; ML 228;ML-228;CID-46742353;N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine;N-([1,1-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine;1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-
- 中文名:
- KC7F2
- 中文别名:
- 化合物ML228;ML 228,HIF通路激活剂
- CBNumber:
- CB42744612
- 分子式:
- C27H21N5
- 分子量:
- 415.49
- MOL File:
- 1357171-62-0.mol
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KC7F2化学性质
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沸点:
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686.0±65.0 °C(Predicted)
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密度:
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1.228±0.06 g/cm3(Predicted)
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储存条件:
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-20°C, Inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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2.03±0.63(Predicted)
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颜色:
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Pale Yellow to Light Yellow
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KC7F2性质、用途与生产工艺
ML228 (CID-46742353) 是一种有效的 HIF 信号通路激活剂，EC50 为 1 μM。ML228 可激活 HIF 以及下游 EGFR。
ML228 (CID-46742353) represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications.
ML228 (injection; 1 µg/kg; 7 days) treatments following spinal cord injury (SCI) improves the local hypoxic ischemia environment, reduce SCI secondary injury and promote the recovery of neurological function.
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Animal Model:
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SD rat
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Dosage:
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1 µg/kg
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Administration:
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injection; 7 days
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Result:
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Alleviated SCI of the central nervous system and relieve associated symptoms.
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KC7F2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-12754 | ML228 | | 1 mg | 450元 |
| 2024/01/25 | HY-12754 | KC7F2
ML228 | 1357171-62-0 | 5mg | 990元 |
1357171-62-0, KC7F2 相关搜索:
- 高端化学
- C27H21N5
- ML 228,HIF通路激活剂
- 化合物ML228
- 1357171-62-0
- 1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-
- L-228
- ML-228;CID-46742353
- CID-46742353
- N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
- ML228; ML 228
- N-([1,1-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
- ML-228