BMS309403
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- CAS号:
- 300657-03-8
- 英文名:
- 2''-(5-ETHYL-3,4-DIPHENYL-PYRAZOL-1-YL)-BIPHENYL-3-YLOXY]ACETIC ACID
- 英文别名:
- CS-495;BMS309403;BMS 309403;BMS309403;BMS-309403 >=98% (HPLC);3-[2-(5-ETHYL-3,4-DIPHENYLPYRAZOL-1-YL)PHENYL]PHENOXYACETIC ACID;2''-(5-ETHYL-3,4-DIPHENYL-PYRAZOL-1-YL)-BIPHENYL-3-YLOXY]ACETIC ACID;2-[3-[2-(5-ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid;2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid;2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]- acetic acid;Acetic acid, 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-
- 中文名:
- BMS309403
- 中文别名:
- 化合物BMS-309403;2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸;2'-(5-乙基-3,4-二苯基-吡唑-1-基)-双苯基-3-氧基]乙酸;2-[[2'-(5-乙基-3,4-二苯基-1H-吡唑-1-基)[1,1'-联苯]-3-基]氧基]乙酸
- CBNumber:
- CB31519335
- 分子式:
- C31H26N2O3
- 分子量:
- 474.55
- MOL File:
- 300657-03-8.mol
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BMS309403化学性质
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沸点:
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657.5±55.0 °C(Predicted)
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密度:
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1.17
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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Soluble in DMSO (up to at lease 25 mg/ml).
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形态:
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White powder solid.
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酸度系数(pKa):
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3.15±0.10(Predicted)
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颜色:
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Off-white or pale yellow
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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BMS309403性质、用途与生产工艺
BMS309403是FABP4小分子抑制剂,Kd值为4 nM,对FABP4的选择性比对FABP5和FABP3高100倍以上。
Target | Value |
FABP4
(Cell-free assay)
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4 nM(Kd)
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Treatment with BMS-309403 significantly decreased MCP-1 production from THP-1 macrophages in a dose- and time-dependent manner.
BMS-309403 sodium (15 mg/kg; chronic treatment; daily for 6 weeks) improves endothelial function, phosphorylated and total eNOS and reduced plasma triglyceride levels but did not affect endothelium-independent relaxations.
Animal Model:
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C57BL/6J mice (ApoE
−/−
mice)
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Dosage:
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15 mg/kg
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Administration:
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Chronic treatment ; daily for 6 weeks
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Result:
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Significantly increased the phosphorylated eNOS (Ser1177) and total eNOS but not the phosphorylated to total eNOS ratio in aortae of 18 weeks old ApoE
−/−
mice.
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BMS309403
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-101903 | BMS309403 BMS-309403 | 300657-03-8 | 5mg | 700元 |
2024/01/25 | HY-101903 | BMS309403 BMS-309403 | 300657-03-8 | 10mM * 1mLin DMSO | 770元 |
300657-03-8, BMS309403 相关搜索:
- selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2)
- FABP4 Inhibitor
- 合成有机化合物配体
- 小分子API
- 合成材料中间体
- 抑制剂
- 试剂
- 化合物BMS-309403
- 2'-(5-乙基-3,4-二苯基-吡唑-1-基)-双苯基-3-氧基]乙酸
- 2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸
- 2-[[2'-(5-乙基-3,4-二苯基-1H-吡唑-1-基)[1,1'-联苯]-3-基]氧基]乙酸
- 300657-03-8
- 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid
- BMS-309403 >=98% (HPLC)
- 2-[3-[2-(5-ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid
- Acetic acid, 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-
- BMS 309403;BMS309403
- CS-495
- 3-[2-(5-ETHYL-3,4-DIPHENYLPYRAZOL-1-YL)PHENYL]PHENOXYACETIC ACID
- BMS309403
- 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]- acetic acid
- 2''-(5-ETHYL-3,4-DIPHENYL-PYRAZOL-1-YL)-BIPHENYL-3-YLOXY]ACETIC ACID