D-苏式-鞘胺醇-1-磷酸
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- CAS号:
- 26993-30-6
- 英文名:
- D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
- 英文别名:
- SPA;S1P;SPHINGOSINE-1-PHOSPHATE;1-SPP;SPN-1-P;SPHINGOSINE-1-PO4;Quetiapine Impurity 54-d8;SPHINGOSINE-1-PHOSPHORIC ACID;Sphingosine-1-phosphate (d18:1);D-erythro-Sphingosin-1-phosphate
- 中文名:
- D-苏式-鞘胺醇-1-磷酸
- 中文别名:
- A蛋白;蛋白A(重组);1-磷酸鞘氨醇;D-苏式-鞘胺醇;D-赤型神经胺磷酸盐;D-赤型鞘氨醇-1-磷酸;D-赤-鞘氨醇-1-磷酸;D-苏式-鞘胺醇-1-磷酸;D-赤型神经胺磷酸盐 1MG;1-磷酸鞘氨醇(D18:1)
- CBNumber:
- CB4181497
- 分子式:
- C18H38NO5P
- 分子量:
- 379.47
- MOL File:
- 26993-30-6.mol
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D-苏式-鞘胺醇-1-磷酸化学性质
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熔点:
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179-189°C
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沸点:
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548.8±60.0 °C(Predicted)
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密度:
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1.094±0.06 g/cm3(Predicted)
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RTECS号:
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RG2260500
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储存条件:
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-20°C
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溶解度:
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methanol: THF: water (6:3:1): >0.5 mg/mL
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形态:
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waxy solid
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酸度系数(pKa):
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1.76±0.10(Predicted)
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颜色:
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yellow
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敏感性:
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Light Sensitive
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稳定性:
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Moisture, Temperature Sensitive; Hygroscopic
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CAS 数据库:
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26993-30-6(CAS DataBase Reference)
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D-苏式-鞘胺醇-1-磷酸性质、用途与生产工艺
Sphingosine-1-phosphate (S1P) 是 S1P1-5 受体 (S1P1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使，动员 Ca2+ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。
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Human Endogenous Metabolite
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S1P (1 μM) induces a significant Ca
2+
releases in HEK293 cells under serum starvation conditions (1% FCS).In a functional Ca
2+
assay, Suramin (HY-B0879) alone does not exert any effect on intracellular Ca
2+
release via gpr3, gpr6 or gpr12. In contrast, S1P (1 μM) induces Ca
2+
release of gpr3, gpr6 and gpr12 in the presence of Suramin (HY-B0879) various concentrations in transfected HEK293 cells.
In a functional Ca
2+
assay,S1P (3-3000 nM) in the presence Suramin (300 μM), exhibits nanomolar EC
50
values for gpr3 (EC
50
=29 nM), gpr6 (EC
50
=15 nM) and gpr12 (EC
50
=24 nM), rat gpr3 (EC
50
=68 nM),respectively in HEK293 cells.
S1P increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and G
qi5
, which allows for phospholipase C stimulation by G
i
proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC
50
s = 8 and 11 nM, respectively).
D-苏式-鞘胺醇-1-磷酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | C32852 | D-赤型神经胺磷酸盐 1MG
D-erythro-Sphingosine 1-phosphate, 96% | 26993-30-6 | 1mg | 3020元 |
| 2024/04/30 | HY-108496 | Sphingosine-1-phosphate | | 1 mg | 1890元 |
26993-30-6, D-苏式-鞘胺醇-1-磷酸 相关搜索:
- Lysophospholipid receptor and related
- Sphingolipids
- Sphingoid bases
- Sphingoid base 1-phosphatesCell Signaling and Neuroscience
- Lipids in Cell Signaling
- Cancer Research
- Angiogenesis
- Angiogenic FactorsSphingolipids
- Protein Kinase Inhibitors and Activators
- Inhibitors
- Glycerols
- Fatty Acid Derivatives & Lipids
- Activators
- Chemical Activators
- proteins
- 代谢物
- 试剂盒-Elisa试剂盒
- 生化试剂-蛋白质
- 脂类
- 蛋白质类
- C18H38NO5P
- D-赤-鞘氨醇-1-磷酸
- D-赤型鞘氨醇-1-磷酸
- 1-磷酸鞘氨醇(D18:1)
- (2S,3R,4E)-2-氨基-4-十八碳烯-1,3-二醇1-(磷酸二氢酯)
- D-赤型神经胺磷酸盐 1MG
- 1-磷酸鞘氨醇
- D-苏式-鞘胺醇
- 蛋白A/A蛋白/PROTEIN A/SPA
- A蛋白
- D-赤型神经胺磷酸盐
- D-苏式-鞘胺醇-1-磷酸
- 蛋白A(重组)
- 26993-30-6
- Quetiapine Impurity 54-d8
- S1P
- SPHINGOSINE-1-PHOSPHATE
- SPA
- D-erythro-Sphingosine-1-phosphate - CAS 26993-30-6 - Calbiochem
- Sphingosine-1-phosphate (d18:1)
- 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-
- Mouse Sphingosine-1-phosphate elisa kit
- (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
- 4-[(9-β-D-Ribofuranosyl-9H-purin-6-yl)amino]-benzenesulfonic acid sodium-potassium salt
- (2S,3R,E)-2-aMino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
- (2S,3R,4E)-2-AMino-4-octadecene-1,3-diol 1-(Dihydrogen phosphate)
- (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid
- (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate
- 1,3-Octadecanediol, 2-amino-, 1-(dihydrogen phosphate), D-erythro- (8C I)
- D-erythro-Sphingosin-1-phosphate
- D-erythro-Sphingosine 1-phosphate,96%
- SHINGOSINE-1-PHOSPHATE \ EDG-1 RECEPTOR
- SPN-1-P
- SPHINGOSINE-1-PO4
- SPHINGOSINE-1-PHOSPHORIC ACID
- SPHINGOSINE-1-PHOSPHATE, D-ERYTHRO
- D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
- D-ERYTHRO-DIHYDROSPHINGOSINE-1-PHOSPHATE