磷苯妥英钠
|
|
- CAS号:
- 92134-98-0
- 英文名:
- Fosphenytoin sodium
- 英文别名:
- CI 982;Cetebyx;ACC-9653;FOSPENYTOIN;ACC 9653-010;Pro-Epanutin;FOSPHENYTOIN SODIUM;Fosphenytion SodiuM;Fosphenytoin SodiuM USP;FOSPHENYTOIN DISODIUM SALT
- 中文名:
- 磷苯妥英钠
- 中文别名:
- 磷苯妥英钠;磷烯菌素二钠盐;苯妥英杂质11(磷苯妥英双钠盐);(2,5-二氧代-4,4-二苯基咪唑啉-1-基)甲基磷酸二钠盐;2,4-咪唑啉二酮-5,5-二苯基-3-[(膦酰氧基)甲基]二钠盐
- CBNumber:
- CB4692780
- 分子式:
- C16H16N2NaO6P
- 分子量:
- 386.28
- MOL File:
- 92134-98-0.mol
|
|
|
磷苯妥英钠化学性质
-
熔点:
-
220° (softens)
-
|
-
储存条件:
-
Inert atmosphere,2-8°C
-
|
-
溶解度:
-
H2O: ≥15mg/mL
-
|
-
形态:
-
powder
-
|
-
颜色:
-
white to tan
-
|
磷苯妥英钠性质、用途与生产工艺
苯妥英钠注射液已广泛用于急性治疗症状性癫痫的药物。但作为急救药物,它只能用于静脉滴注,并且注射部位局部疼痛、红肿、难以忍受。1997年美国FDA停用苯妥英钠注射液,文献报道英国亦考虑停用苯妥英钠注射液。磷苯妥英钠注射液是美国WannerLambert公司开发的苯妥英钠注射液升级换代产品。磷苯妥英钠是苯妥英前体药物,它在体内经膦酸酯酶迅速水解而全部转化为苯妥英,1996年9月美国FDA批准上市,1999年在英国上市。磷苯妥英钠的水溶性是苯妥英钠的4000倍,水溶液pH值8.6~12,从而克服了苯妥英钠临床使用带来的不良反应,因而成为疗效好、安全性高、刺激性小的抗癫痫新药。
适用于急性治疗症状性癫痫以及预防和治疗进行神经手术或头部创伤病人的中风。
静注磷苯妥英钠注射液注射部位难以忍受的情况仅为9%,注射过程中断率为21%,平均注射时间为13min,较苯妥英钠注射液注射部位难以忍受分别为90%,注射过程中断率67%和平均注射时间44min有了很大的提高。使必须用苯妥英钠注射液的患者又快又好地接受治疗、耐受性好、中断治疗少,不良反应少。
Fosphenytoin (disodium)是fosphenytoin的钠盐形式,fosphenytoin是一种前体药物,在肠胃外给药可水解成具有抗惊厥作用的苯妥英。
Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg).
磷苯妥英钠
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | S6482 | 磷苯妥英钠 Fosphenytoin (disodium) | 92134-98-0 | 5mg | 794.54元 |
2022/04/29 | S6482 | 磷苯妥英钠 Fosphenytoin (disodium) | 92134-98-0 | 100mg | 2842.84元 |
磷苯妥英钠
生产厂家
全球有 163家供应商
磷苯妥英钠国内生产厂家
92134-98-0, 磷苯妥英钠 相关搜索:
- API
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- 化学试剂
- 药靶配体
- 医药原料
- 神经系统用药
- C16H13N2O6P2NaH2O
- C16H15N2O6P2Na
- C16H13N2Na2O6P
- C16H13N2O6P2Na
- 苯妥英杂质11(磷苯妥英双钠盐)
- 磷烯菌素二钠盐
- (2,5-二氧代-4,4-二苯基咪唑啉-1-基)甲基磷酸二钠盐
- 磷苯妥英钠
- 2,4-咪唑啉二酮-5,5-二苯基-3-[(膦酰氧基)甲基]二钠盐
- 92134-98-0
- Sodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
- isodium,(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methylphosphate
- Phenytoin Impurity 11(Fosphenytoin Disodium Salt)
- Fosphenytoin Sodium (1286366)
- Fosphenytoin Sodium (ACC-9653)
- disodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
- Fosphenytoin (sodium salt)
- Fosphenytoin disodium salt hydrate
- 5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt hydrate
- Fosphenytoin SodiuM USP
- Pro-Epanutin
- CI 982
- Cetebyx
- ACC 9653-010
- 5,5-Diphenyl-3-[(phosphonooxy)Methyl]-2,4-iMidazolidinedione SodiuM Salt
- Fosphenytion SodiuM
- Fosphenytoin Sodium (250 mg)
- ACC-9653
- 5,5-Diphenyl-3-[[[di(sodiooxy)phosphinyl]oxy]methyl]-1H-imidazole-2,4(3H,5H)-dione
- FOSPHENYTOIN DISODIUM SALT
- FOSPENYTOIN
- (sp-4-2)-5,5-diphenyl-3-((phosphonooxy)methyl)-2,4-imidazolidinedione disodium salt
- FOSPHENYTOIN SODIUM
- Fosphenytoin Sodium (350 mg)
- 5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt