2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺
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- CAS号:
- 152095-12-0
- 英文名:
- Iron Chelator, Dp44mT
- 英文别名:
- de44mt;Dp44mT;CS-2521;Iron Chelator;Iron Chelator, Dp44mT;Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone;2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide;2-(di(pyridin-2-yl)methylene)-N,N-imethylhydrazinecarbothioamide;2-(Di(pyridin-2-yl)methylene)-N,N-dimethylhydrazinecarbothioamide;Hydrazinecarbothioamide, 2-(di-2-pyridinylmethylene)-N,N-dimethyl-
- 中文名:
- 2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺
- 中文别名:
- 铁螯合剂,DP44MT;2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺
- CBNumber:
- CB52524488
- 分子式:
- C14H15N5S
- 分子量:
- 285.37
- MOL File:
- 152095-12-0.mol
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2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥5mg/mL
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形态:
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powder
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颜色:
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yellow to orange
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敏感性:
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Light Sensitive
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may ne stored at -20°C for 1 month.
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2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺性质、用途与生产工艺
Dp44mT是具有选择性抗癌活性的铁螯合剂 (iron chelator)。
Dp44mT is cytotoxic to breast cancer cells, at least in part, due to selective inhibition of top2α. Dp44mT alone induced selective cell killing in the breast cancer cell line MDA-MB-231 when compared with healthy mammary epithelial cells (MCF-12A). It induces G1 cell cycle arrest and reduces cancer cell clonogenic growth at nanomolar concentrations. Dp44mT, but not the iron chelator desferal, induces DNA double-strand breaks quantified as S139 phosphorylated histone foci (γ-H2AX) and Comet tails induced in MDA-MB-231 cells. Doxorubicin-induced cytotoxicity and DNA damage are both enhanced significantly in the presence of low concentrations of Dp44mT. The chelator caused selective poisoning of DNA topoisomerase IIα (top2α) as measured by an
in vitro
DNA cleavage assay and cellular topoisomerase-DNA complex formation. Dp44mT targets lysosome integrity through copper binding. Copper binding is essential for the potent antitumor activity of Dp44mT, as coincubation with nontoxic copper chelators markedly attenuated its cytotoxicity.
2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-18973 | Dp44mT | | 5 mg | 375元 |
| 2024/01/25 | HY-18973 | 2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺
Dp44mT | 152095-12-0 | 10mg | 600元 |
2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺
生产厂家
152095-12-0, 2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺 相关搜索:
- 药靶配体
- 抑制剂
- 铁螯合剂,DP44MT
- 2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺
- 152095-12-0
- 2-(di(pyridin-2-yl)methylene)-N,N-imethylhydrazinecarbothioamide
- 2-(Di(pyridin-2-yl)methylene)-N,N-dimethylhydrazinecarbothioamide
- Hydrazinecarbothioamide, 2-(di-2-pyridinylmethylene)-N,N-dimethyl-
- Iron Chelator
- CS-2521
- de44mt
- Dp44mT
- Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone
- 2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide
- Iron Chelator, Dp44mT