Α-(三氯甲基)-4-吡啶乙醇
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- CAS号:
- 10129-56-3
- 英文名:
- ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- 英文别名:
- PETCM;APOPTOSIS ACTIVATOR I;α-(Trichloromethyl)-4-pyridineethanol;a-(Trichloromethyl)-4-pyridineethanol;4-Pyridineethanol, α-(trichloromethyl)-;1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL;ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL;1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE;α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
- 中文名:
- Α-(三氯甲基)-4-吡啶乙醇
- 中文别名:
- 化合物 T12413;Α-(三氯甲基)-4-吡啶乙醇;Α-(三氯甲基)-4-吡啶乙醇;PETCM,半胱氨酸蛋白酶-3激活剂;ALPHA-(三氯甲基)-4-吡啶乙醇
- CBNumber:
- CB8197667
- 分子式:
- C8H8Cl3NO
- 分子量:
- 240.51
- MOL File:
- 10129-56-3.mol
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Α-(三氯甲基)-4-吡啶乙醇化学性质
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沸点:
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342.2±37.0 °C(Predicted)
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密度:
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1.465±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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DMSO: 22 mg/mL, soluble
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形态:
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solid
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酸度系数(pKa):
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12.07±0.20(Predicted)
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颜色:
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Light yellow to light brown
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Α-(三氯甲基)-4-吡啶乙醇性质、用途与生产工艺
PETCM 是 caspase-3 的激活剂,以细胞色素 c (cyto c) 依赖的方式起作用。PETCM 可促进 Apaf-1 低聚化,可诱导 HeLa 细胞的凋亡 (apoptosis)。
PETCM (0.1-0.5 mM) stimulates caspase-3 activity (DEVD activity) of HeLa S-100 in a dose-dependent manner.And 0.2 mM PETCM is more efficient in activating caspase-3 than 1 mM dATP.PETCM (0.2 mM; 1 hour) drives apoptosome formation. Apaf-1 in a normal HeLa cell S-100 fraction is in an inactive monomeric form. After 1 mM dATP, most of the Apaf-1 shifted to a size of 1 million daltons. After the S-100 fraction with 0.2 mM PETCM, Apaf-1 exhibits a similar shift. And the efficiency of apoptosome formation was better with 0.2 mM PETCM.PETCM (0.2 mM; 1 hour) can antagonize the inhibitory activity of ProT reduced caspase-3 activation in in HeLa cells.
Western Blot Analysis
Cell Line:
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HeLa cells
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Concentration:
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0.2 mM
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Incubation Time:
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1 hour
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Result:
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Increased apoptosome formation.
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Α-(三氯甲基)-4-吡啶乙醇
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-103349 | Α-(三氯甲基)-4-吡啶乙醇 PETCM | 10129-56-3 | 5mg | 500元 |
2024/08/19 | HY-103349 | PETCM | | 10 mM * 1 mLin DMSO | 550元 |
10129-56-3, Α-(三氯甲基)-4-吡啶乙醇 相关搜索:
- Caspase/Related products.
- 合成有机化合物配体
- BioChemical
- Apoptosis Inducers
- Apoptosis and Cell Cycle
- Cell Signaling and Neuroscience
- Cell Biology
- C8H8NOCl3
- C8H8Cl3NO
- PETCM,半胱氨酸蛋白酶-3激活剂
- 化合物 T12413
- Α-(三氯甲基)-4-吡啶乙醇
- ALPHA-(三氯甲基)-4-吡啶乙醇
- Α-(三氯甲基)-4-吡啶乙醇
- 10129-56-3
- 4-Pyridineethanol, α-(trichloromethyl)-
- α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
- α-(Trichloromethyl)-4-pyridineethanol
- a-(Trichloromethyl)-4-pyridineethanol
- 1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL
- 1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE
- ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- APOPTOSIS ACTIVATOR I
- PETCM