TMP269
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- CAS号:
- 1314890-29-3
- 英文名:
- TMP269
- 英文别名:
- TMP269;CS-1345;TMP269, >=98%;TMP 269; TMP-269;TMP269 TMP-269 HDACIIa Inhibitor;N-((4-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxad;N-{[4-(4-phenyl-1,3-thiazol-2-yl)oxan-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide;N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)Methyl)-3-(5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl)benzaMide;N-[[Tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide;BenzaMide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]Methyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]-
- 中文名:
- TMP269
- 中文别名:
- 化合物TMP269;脱乙酰化酶抑制剂(HDAC抑制剂)(TMP269);N-((4-(4-苯基噻唑-2-基)四氢-2H-吡喃-4-基)甲基)-3-(5-(三氟甲基)-1,2,4-恶二唑-3-基)苯甲酰胺;N-[[四氢-4-(4-苯基-2-噻唑基)-2H-吡喃-4-基]甲基]-3-[5-(三氟甲基)-1,2,4-恶二唑-3-基]苯甲酰胺
- CBNumber:
- CB82667421
- 分子式:
- C25H21F3N4O3S
- 分子量:
- 514.52
- MOL File:
- 1314890-29-3.mol
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TMP269化学性质
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密度:
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1.347±0.06 g/cm3(Predicted)
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储存条件:
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Amber Vial, -20°C Freezer, Under inert atmosphere
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溶解度:
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≥23 mg/mL in DMSO; insoluble in H2O; ≥21 mg/mL in EtOH with ultrasonic
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形态:
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solid
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酸度系数(pKa):
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13.66±0.46(Predicted)
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TMP269性质、用途与生产工艺
TMP269 是强效的选择性的IIa类HDAC抑制剂,其作用于HDAC4, HDAC5, HDAC7 和 HDAC9的IC50分别为126 nM, 80 nM, 36 nM 和 19 nM。
Target | Value |
HDAC9
(Cell-free assay)
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23 nM
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HDAC7
(Cell-free assay)
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43 nM
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HDAC5
(Cell-free assay)
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97 nM
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HDAC4
(Cell-free assay)
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157 nM
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TMP269在10 μM浓度下对线粒体活性和/或人CD4+ T细胞的活性没有影响,并且可以被用作鉴定IIa类HDAC酶内源性底物的工具。在IEC-18小肠上皮细胞中,TMP269阻止应答G蛋白偶联受体/PKD1活化引起的细胞进程,DNA合成,以及增殖。
TMP269
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-18360 | TMP269 TMP269 | 1314890-29-3 | 2mg | 640元 |
2024/01/25 | HY-18360 | TMP269 TMP269 | 1314890-29-3 | 5mg | 1100元 |
1314890-29-3, TMP269 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 标准品
- 细胞生物学试剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- 化合物TMP269
- N-((4-(4-苯基噻唑-2-基)四氢-2H-吡喃-4-基)甲基)-3-(5-(三氟甲基)-1,2,4-恶二唑-3-基)苯甲酰胺
- 脱乙酰化酶抑制剂(HDAC抑制剂)(TMP269)
- N-[[四氢-4-(4-苯基-2-噻唑基)-2H-吡喃-4-基]甲基]-3-[5-(三氟甲基)-1,2,4-恶二唑-3-基]苯甲酰胺
- 1314890-29-3
- TMP269 TMP-269 HDACIIa Inhibitor
- N-{[4-(4-phenyl-1,3-thiazol-2-yl)oxan-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide
- CS-1345
- TMP 269; TMP-269
- N-{[4-(4-phenyl-1,3-thiazol-2-yl)tetrahydro-2h-pyran-4-yl]methyl} -3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide
- N-((4-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxad
- TMP269, >=98%
- N-[[Tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide
- N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)Methyl)-3-(5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl)benzaMide
- TMP269
- BenzaMide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]Methyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]-
- TMP269 N-[[Tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide
- N-[[Tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide TMP269