O-单乙酰更昔洛韦
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- CAS号:
- 88110-89-8
- 英文名:
- Ganciclovir Mono-O-acetate
- 英文别名:
- Monacetyl ganciclor;Mono acetyl Ganciclovir;Gancyclovir Impurity 20;Valganciclovir USP RC E;Ganciclovir Impurity 30;Ganciclovir Impurity 16;O-Monoacetylganciclovir;Mono-O-AcetylGanciclovir;Mono-O-acetateGanciclovir;Ganciclovir Mono-O-acetate
- 中文名:
- O-单乙酰更昔洛韦
- 中文别名:
- 更年期30;单乙酰更昔洛;单乙酰更昔洛韦;更昔洛韦单乙酸盐;更昔洛韦一乙酸酯;更昔洛韦杂质30;更昔洛韦单乙酸酯;更昔洛韦杂质16;O-单乙酰更昔洛韦;盐酸缬更昔洛韦杂质E
- CBNumber:
- CB91176343
- 分子式:
- C11H15N5O5
- 分子量:
- 297.27
- MOL File:
- 88110-89-8.mol
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O-单乙酰更昔洛韦化学性质
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熔点:
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194-197°C
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密度:
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1.66±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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9.32±0.20(Predicted)
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形态:
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Solid
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颜色:
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White
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O-单乙酰更昔洛韦性质、用途与生产工艺
9-[[2-(乙酰氧基)-1-(羟基甲基)乙氧基]甲基]-2-氨基-1,9-二氢-6H-嘌呤-6-酮即O-单乙酰更昔洛韦,作为缬更昔洛韦的主要原材料之一,应用非常广泛。缬更昔洛韦为合成的2-脱氧鸟苷类似物,是抗病毒药更昔洛韦(ganciclovir)的前体药物,可大大减少更昔洛韦的毒性。
S1、将40kg三乙酰更昔洛韦、120kg吡啶投入500L反应釜中,并加入4kg水,搅拌升温至70℃;
S2、保温反应12小时后取样检测(HPLC),检测结果如图1和表1所示,由图1和表1可知,单乙酰更昔洛韦含量明显在增加,三乙酰更昔洛韦含量在下降;
S3、保温反应36小时后取样检测,检测结果如图2和表2所示,由图2和表2可知,保温反应已反应完全;
S4、升温至100℃并减压,收集蒸发出的水汽和吡啶,此时反应釜中保留呈液态的主反应物和部分水,然后另行将吡啶减压蒸干,回收利用;
S5、加入200kg乙酸乙酯至反应釜中,搅拌回流3小时,然后进行降温析晶;
S6、离心处理,实现固液分离后,收集固体经过烘干处理,得O-单乙酰更昔洛韦成品29.2kg;收集液体,蒸馏,回收乙酸乙酯。
经计算可得,O-单乙酰更昔洛韦的收率为93.7%。
O-单乙酰更昔洛韦
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-41344 | O-单乙酰更昔洛韦 Ganciclovir mono-O-acetate | 88110-89-8 | 50mg | 350元 |
88110-89-8, O-单乙酰更昔洛韦 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- 137-更昔洛韦
- 标准品
- 化工中间体
- 杂质对照品
- 化学中间体
- 更昔洛韦中间体
- 医药原料
- O-单乙酰更昔洛韦 99%MIN VGCV
- 更昔洛韦杂质16
- 更昔洛韦单乙酸酯
- 更昔洛韦杂质30
- 单乙酰更昔洛
- 盐酸缬更昔洛韦杂质E
- 更昔洛韦一乙酸酯
- 2-((2-氨基-6-氧代-1H-嘌呤-9(6H)-基)甲氧基)-3-羟基丙基乙酸酯
- 更年期30
- 单乙酰更昔洛韦
- 更昔洛韦单乙酸盐
- MONO-O-乙酰更昔洛韦
- O-单乙酰更昔洛韦(杂质对照品)
- 更昔洛韦单-O-乙酸酯
- 9-[[2-(乙酰氧基)-1-(羟基甲基)乙氧基]甲基]-2-氨基-1,9-二氢-6H-嘌呤-6-酮
- O-单乙酰更昔洛韦
- 88110-89-8
- O-Monoacetylganciclovir
- 3-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-6,7-dihydroxy-3,5,6,7- tetrahydro-9H-imidazo[1,2-a]purin-9-one
- Ganciclovir Impurity 16
- 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydro...
- Valganciclovir Related Compound E (Monoacetoxy Ganciclovir)
- Ganciclovir Impurity 30
- Monacetyl ganciclor
- valganciclovirhydrochloride iMpurit E
- Ganciclovir Mono-O-acetate ISO 9001:2015 REACH
- 2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate
- Valganciclovir USP RC E
- Mono-O-acetateGanciclovir(Impuritycontrol)
- [2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] acetate
- 6h-purin-6-one,9-[[2-(acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro-
- Gancyclovir Impurity 20
- Mono-O-AcetylGanciclovir
- Mono acetyl Ganciclovir
- Mono-O-acetateGanciclovir
- 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol
- 2-[(2-aMino-6-oxo-3,6-dihydro-9H-purin-9-yl)Methoxy]-3-hydroxypropyl acetate
- Ganciclovir-Mono-O-acetate(Mono-O-AcetylGanciclovir)
- 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-one
- Ganciclovir Mono-O-acetate
- 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-on