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2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one
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- CAS号:
- 2514-30-9
- 英文名:
- 2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one
- 英文别名:
- PBIT;CS-1495;PBIT, >=98%;PBIT >=98% (HPLC);JUMONJI HDM INHIBITOR;2-p-Tolyl-1,2-benzisothiazolin-3-one;2-(p-Tolyl)benzo[d]isothiazol-3(2H)-one;2-(4-methylphenyl)-1,2-benzothiazol-3-one;Histone Demethylase,Inhibitor,PBIT,inhibit;1,2-Benzisothiazol-3(2H)-one, 2-(4-methylphenyl)-
- 中文名:
- 2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one
- 中文别名:
- 化合物PBIT;2-(对甲苯基)苯并[D]异噻唑-3(2H)-酮;PBIT,JARID1(JUMONJI AT-RICH交互式域1)抑制剂
- CBNumber:
- CB92681578
- 分子式:
- C14H11NOS
- 分子量:
- 241.31
- MOL File:
- 2514-30-9.mol
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2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one化学性质
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熔点:
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136.7-137.1 °C(Solv: benzene (71-43-2); hexane (110-54-3))
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沸点:
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418.2±38.0 °C(Predicted)
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密度:
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1.297±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear (warmed)
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酸度系数(pKa):
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-0.03±0.20(Predicted)
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形态:
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powder
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颜色:
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white to beige
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one性质、用途与生产工艺
PBIT 是一种特异性的 Jumonji/AT 富集互作结构域 1 (JARID1) 抑制剂。PBIT 抑制 JARID1B (KDM5B 或 PLU1) 组蛋白去甲基化酶， IC50 值约为 3 μM。 PBIT 还抑制 JARID1A 和 JARID1C，IC50 分别为 6 μM 和 4.9 μM。
IC50: 3 μM (JARID1B), 6 μM (JARID1A), 4.9 μM (JARID1C)
PBIT inhibits proliferation of cells expressing higher levels of JARID1B. PBIT (1-10 μM for UACC-812 cells, 2.5-10μM for MCF7 and MCF10A cells; 72 hours) inhibits cell proliferation in a JARID1B level-dependent manner.
Cell Proliferation Assay
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Cell Line:
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Human breast cancer cell lines (UACC-812 and MCF7) and human mammary epithelial cells (MCF10A)
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Concentration:
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1, 3, and 10 μM for UACC-812 cells; 2.5, 5, and 10 μM for MCF7 and MCF10A cells
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Incubation Time:
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72 hours
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Result:
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Inhibited cell proliferation in a JARID1B level-dependent manner. 10 μM killed most of the UACC-812 cells, but showed minimal toxicity to MCF7 cells and MCF10A cells.
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2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-101451 | PBIT | | 1 mg | 400元 |
| 2024/04/30 | HY-101451 | 2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one
PBIT | 2514-30-9 | 5mg | 1000元 |
2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one
生产厂家
2514-30-9, 2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one 相关搜索:
- 合成有机化合物配体
- PBIT,JARID1(JUMONJI AT-RICH交互式域1)抑制剂
- 2-(对甲苯基)苯并[D]异噻唑-3(2H)-酮
- 化合物PBIT
- 2514-30-9
- Histone Demethylase,Inhibitor,PBIT,inhibit
- 2-(p-Tolyl)benzo[d]isothiazol-3(2H)-one
- PBIT >=98% (HPLC)
- 1,2-Benzisothiazol-3(2H)-one, 2-(4-methylphenyl)-
- 2-(4-methylphenyl)-1,2-benzothiazol-3-one
- CS-1495
- JUMONJI HDM INHIBITOR
- PBIT, >=98%
- PBIT
- 2-p-Tolyl-1,2-benzisothiazolin-3-one
- 2-(4-Methylphenyl)-2,3-dihydrobenzisothiazol-3-one
- 2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one