Allisartan Isoproxil

Allisartan Isoproxil Struktur
947331-05-7
CAS-Nr.
947331-05-7
Englisch Name:
Allisartan Isoproxil
Synonyma:
Allisartan;Losartan Impurity N9;Allisartan Isoproxil;Losartan Impurity 19(Allisartan Isoproxil);1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, [[(1-methylethoxy)carbonyl]oxy]methyl ester
CBNumber:
CB03159860
Summenformel:
C27H29ClN6O5
Molgewicht:
553.01
MOL-Datei:
947331-05-7.mol

Allisartan Isoproxil Eigenschaften

Siedepunkt:
745.0±70.0 °C(Predicted)
Dichte
1.35±0.1 g/cm3(Predicted)
pka
4.16±0.10(Predicted)

Sicherheit

Allisartan Isoproxil Chemische Eigenschaften,Einsatz,Produktion Methoden

Clinical Use

Allisartan isoproxil, a member of a new class of selective angiotensin II-1 receptor antagonists, was approved by the Chinese Food and Drug Administration (CFDA) for the treatment of hypertension in July 2012.19 At time of publication, there is no trade name associated with this drug. Allisartan was discovered and developed by the Chinese biomedical company Allist Pharmaceuticals. Allisartan isoproxil is a prodrug which is readily hydrolyzed to active metabolite EXP3174, which is also the active metabolite of losartan (des-triphenylmethyl-9).

Synthese

Although several synthetic routes have been reported within two patents, the most likely scalable process route is described in the scheme. Commercial 2-butyl-4-chloro-5-(hydroxymethyl)-imidazole (7) was alkylated with Ntriphenylmethyl- 5-(4'-bromomethylbiphenyl-2-yl)tetrazole (8) under basic conditions in warm DMF, providing alcohol 9 in 90% yield. This alcohol was then oxidized to the corresponding carboxylic acid 10 with KMnO4 in 88% yield. Etherification of acid 10 with isopropyl chloromethyl carbonate (11) followed by de-tritylation of the tetrazole group under acidic contidions gave allisartan isoproxil (II) in 69% yield.

Synthesis_947331-05-7

Allisartan Isoproxil Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Allisartan Isoproxil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 30)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10523 58
Hebei Miaoyin Technology Co.,Ltd
+86-17367732028 +86-17367732028
kathy@hbyinsheng.com China 3582 58
Yichang Chanod Biomedical Technology Co,LTD 0717-6855399 15377615856
sales@sndswyy.cn China 83 58
Cdreamlab (Hubei) Technology Co., LTD 0717-6300888 18062399888
service@cdreamlab.com China 315 58
Allikang Pharmaceutical Co., LTD 0573-87390950 13806705416
wzj@alicornpharma.com China 71 58
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
sales@chem-strong.com China 17982 56
Nanjing Chalf-Pharm Technology Co., Ltd. 025-57018978 18251899859
sales@chalf-pharm.com China 5948 50
Chengdu DingDang Pharmaceutical Co., Ltd. 028-86040038 13980902949;
market@dingdangchem.com China 1746 55
ATK CHEMICAL COMPANY LIMITED 3429815786 13301662590
sales@atkchemical.com China 10006 55

947331-05-7()Verwandte Suche:


  • Allisartan Isoproxil
  • 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, [[(1-methylethoxy)carbonyl]oxy]methyl ester
  • Losartan Impurity 19(Allisartan Isoproxil)
  • Allisartan
  • Losartan Impurity N9
  • 947331-05-7
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