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Parthenolide Produkt Beschreibung

Parthenolide Struktur
20554-84-1
CAS-Nr.
20554-84-1
Englisch Name:
Parthenolide
Synonyma:
PTL;Nsc157035;Aids007764;Parthelide;Aids-007764;Parthenolide;PartheNAlide;Parthenolides;parthenolider;Parthenolide>
CBNumber:
CB0446848
Summenformel:
C15H20O3
Molgewicht:
248.32
MOL-Datei:
20554-84-1.mol

Parthenolide Eigenschaften

Schmelzpunkt:
115-116 °C (lit.)
alpha 
D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
Siedepunkt:
394.1±42.0 °C(Predicted)
Dichte
1.13±0.1 g/cm3(Predicted)
storage temp. 
-20°C
Aggregatzustand
White solid
Merck 
14,7048
CAS Datenbank
20554-84-1

Sicherheit

Kennzeichnung gefährlicher Xi,C,F
R-Sätze: 11-34
S-Sätze: 22-24/25-45-36/37/39-26-16
WGK Germany  3
RTECS-Nr. LY4220000
HS Code  29322090

Parthenolide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R11:Leichtentzündlich.
R34:Verursacht Verätzungen.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Beschreibung

Parthenolide is an allergen in feverfew (Tanacetum parthenarium).

Chemische Eigenschaften

White solid

Verwenden

Antiinflammatory;MAP kinase inhibitor

Verwenden

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.

Definition

ChEBI: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).

Biologische Aktivität

The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Parthenolide is antisecretory, anti-inflammatory, spasmolytic and inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B 4 and thromboxane B 2 .

Kontakt-Allergie

Parthenolide is a sesquiterpene lactone found Asteraceae- Compositae such as feverfew (Tanacetum parthenium Schultz-Bip.) or congress grass (Parthenium hysterophorus L.).

Parthenolide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Parthenolide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 321)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 372 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29960 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5460 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58

20554-84-1()Verwandte Suche:


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  • parthenolider
  • 20554-84-1
  • 10-21-7
  • 20552-41-8
  • Anti-Proliferative Agents
  • Antitumor Agents
  • BioChemical
  • Cancer Research
  • inhibitor
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Natural Product
  • Sesqui-Terpenoids
  • Isoprenoid/terpenoidNeurotransmitters
  • Anti-Proliferative AgentsNutrition Research
  • Antitumor Agents
  • Biochemicals Found in Plants
  • Cancer Research
  • Others
  • Serotonergics
  • Prostanoid receptor and related
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