Sodium formaldehydesulfoxylate dihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white crystalline powder
Verwenden
Pharmaceutic aid (preservative).
Vorbereitung Methode
Sodium formaldehyde sulfoxylate is manufactured from sodium
dithionate and formaldehyde in water.
Allgemeine Beschreibung
Oxidation reation of hydroxymethanesulfinic acid with chlorite has been studied in the pH range 4-8. It is a sulfur-containing reducing agent.
Pharmazeutische Anwendungen
Sodium formaldehyde sulfoxylate is a water-soluble antioxidant
and is generally used as the dihydrate. It is used in the formulation
of injection products at a level of up to 0.1% w/v in the final
preparation administered to the patient.
Sicherheit(Safety)
The toxicological properties of sodium formaldehyde sulfoxylate
have not been fully investigated. However, it is used in the
formulation of injection products at a level to 0.1% w/v in the
final preparation administered to the patient.
Sodium formaldehyde sulfoxylate is moderately toxic by
ingestion, and when heated to decomposition it emits toxic fumes
of sulfur dioxide and sodium oxide.
LD50 (mouse, oral): 4 g/kg
LD50 (rat, IP): >2 g/kg
LD50 (rat, oral): >2 g/kg
Lager
Store in well-closed, light-resistant containers at controlled room
temperature (15–30℃).
Inkompatibilitäten
Sodium formaldehyde sulfoxylate is incompatible with strong
oxidizing agents; it is decomposed by dilute acid.
Regulatory Status
Included in the FDA Inactive Ingredients Database (parenteral
products up to 0.1% via the IM, IV, and SC routes). Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
Sodium formaldehydesulfoxylate dihydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
