(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
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- CAS-Nr.
- 915095-94-2
- Englisch Name:
- (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
- Synonyma:
- EMpagliflozin iMpurity C;(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;]phenoxy}oxoL;oro-5-iodophenyL;(3S)-3-{4-[(2-chL;Englitin Impurity 28;Empagliflozin Impurity 110;Empagliflozin Intermediate1;(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc;1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
- CBNumber:
- CB12657939
- Summenformel:
- C17H16ClIO2
- Molgewicht:
- 414.67
- MOL-Datei:
- 915095-94-2.mol
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Eigenschaften
- Siedepunkt:
- 476.0±45.0 °C(Predicted)
- Dichte
- 1.578±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C(protect from light)
- Löslichkeit
- DMSO, Methanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChI
- InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
- InChIKey
- YLUHNGIWRCCQMQ-INIZCTEOSA-N
- SMILES
- O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1
- CAS Datenbank
- 915095-94-2
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.
synthetische
0.5 mol of raw material and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan was obtained through purification.
![(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan](/NewsImg/2023-09-21/6383091813460367816902960.jpg "(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan")
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 370)Lieferanten
915095-94-2()Verwandte Suche:
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
- (S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)-tetrahydrofuran
- (S)-3-(4-(2-chloro-5-fluorobenzyl)phenoxy)-tetrahydrofuran
- (3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane
- (3S)-3-[4-(2-chloro-5-iodobenzyl)-phenoxy]-tetrahydrofuran
- Furan, 3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-, (3S)-
- Empagliflozin Intermediate1
- 3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
- (3S-3-(4)Chloro-5-Iodophenyl)Methyl)Phenoxy)Tetrahydro-Furan
- 1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
- Englitin Impurity 28
- (3S)-3-{4-[(2-chL
- ]phenoxy}oxoL
- oro-5-iodophenyL
- (3S)-3-[4-[(2-CHLORO-5-IODOPHENYL)METHYL]PHENOXY]TETRAHYDRO-FURAN 915095-94-2
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan(For export only)
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan ISO 9001：2015 REACH
- Empagliflozin Impurity 110
- (3S)-3-[4-[(5-Iodo-2-
Chlorophenyl) Methyl]
Phenoxy] Tetrahydrofuran
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-...
- EMpagliflozin iMpurity C
- (S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene
- Empagliflozin Intermediate/ (3S)-3-[4-[(2-Chloro-5-Iodophenyl)Methyl]Phenoxy]Tetrahydro-Furan
- (3S)-3-[4-4(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
- (3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc
- 915095-94-2
- C17H16ClIO2
- Empagliflozin
- Empagliflozin Intermediate
- 915095-94-2
