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ChemicalBook >> CAS DataBase List >>(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Structure
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran structure
CAS No.
915095-94-2
Chemical Name:
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Synonyms
EMpagliflozin iMpurity C;(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;]phenoxy}oxoL;oro-5-iodophenyL;(3S)-3-{4-[(2-chL;Englitin Impurity 28;Empagliflozin Impurity 110;Empagliflozin Intermediate1;(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc;1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
CBNumber:
CB12657939
Molecular Formula:
C17H16ClIO2
Molecular Weight:
414.67
MDL Number:
MFCD28098707
MOL File:
915095-94-2.mol
MSDS File:
SDS
Last updated:2024-04-19 13:56:29
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Properties

Boiling point 476.0±45.0 °C(Predicted)
Density 1.578±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 2-8°C(protect from light)
solubility DMSO, Methanol (Slightly, Sonicated)
form Solid
color White to Off-White
InChI InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
InChIKey YLUHNGIWRCCQMQ-INIZCTEOSA-N
SMILES O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1
CAS DataBase Reference 915095-94-2

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific 9598AF (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2 1g $39 2021-12-16 Buy
AK Scientific J95043 (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2 5g $88 2021-12-16 Buy
SynQuest Laboratories 2H10-M-S0 (3S)-3-{4-[(2-Chloro-5-iodophenyl)methyl]phenoxy}oxolane 97.0% 915095-94-2 250mg $115 2021-12-16 Buy
AK Scientific 9598AF (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2 5g $118 2021-12-16 Buy
AK Scientific 9598AF (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2 10g $189 2021-12-16 Buy
Product number Packaging Price Buy
9598AF 1g $39 Buy
J95043 5g $88 Buy
2H10-M-S0 250mg $115 Buy
9598AF 5g $118 Buy
9598AF 10g $189 Buy

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemical Properties,Uses,Production

Physical Form

Solid

Uses

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran(915095-94-2) can be used as reactant/reagent in preparation of C-?aryl D-?glurofuranoside compounds useful as reference compounds in the quality control of gliflozin type medicine.

Description

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.

Preparation

0.5 mol of raw material and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan was obtained through purification.  
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran synthesis

915095-87-3
915095-94-2
Synthesis of (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran from (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Preparation Products And Raw materials

Raw materials

4-Hydroxybenzyl chloride 4-(2-chloro-5-iodobenzyl)phenol 2-Chloro-5-iodobenzoic acid 2-Chloro-5-iodo-benzoyl chloride Empagliflozin Impurity 35
(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (S)-3-P-MESYLOXYTETRAHYDROFURAN (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 4-Methoxybenzylchloride 4-Iodoaniline

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Preparation Products

1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Suppliers

Global( 370)Suppliers
Supplier Tel Email Country ProdList Advantage
SyncoZymes (Shanghai) Co., Ltd., 		+86-021-68187180-811 +86-13681683526 lchen@syncozymes.com China 188 58
Shanghai Rochi Pharmaceutical Co.,Ltd.
21-38751876 +8615000076078 info@rochipharma.com China 431 58
Porton Pharma Solutions Ltd.
China 56 58
Shanghai Joiny Pharmaceutical Co.,LTD 		+8613681955282 gyd@joiny-pharma.com China 228 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Supplier Advantage
SyncoZymes (Shanghai) Co., Ltd., 		58
Shanghai Rochi Pharmaceutical Co.,Ltd.
58
Porton Pharma Solutions Ltd.
58
Shanghai Joiny Pharmaceutical Co.,LTD 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Hangzhou ICH Biofarm Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55

View Lastest Price from (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan pictures 2024-04-25 (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
915095-94-2
 US $0.00 / Kg/Drum 10g 99% 50mt Jinan Finer Chemical Co., Ltd
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan pictures 2024-04-24 (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
915095-94-2
 US $100.00-70.00 / kilograms 100kilograms 99% 100tons Hebei Dangtong Import and export Co LTD
Empagliflozin Intermediate pictures 2024-04-22 Empagliflozin Intermediate
915095-94-2
 US $1200.00 / Kg/Bag 2Kg/Bag 99% up, High Density 20 tons Sinoway Industrial co., ltd.

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Spectrum

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan(915095-94-2)1HNMR

915095-94-2((S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran)Related Search:

(S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine Thiazole Copper(II) chloride dihydrate Tetrahydrofuran
Dimethyl fumarate 1-Propanol Brexpiprazole Intermediate 1 (R)-3-(p-toluenesulfonyl) oxytetrahydrofuran Empagliflozin
(S)-(+)-3-Hydroxytetrahydrofuran 4-(5-broMo-2-chlorobenzyl)phenol (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone
(2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

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(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)-tetrahydrofuran (S)-3-(4-(2-chloro-5-fluorobenzyl)phenoxy)-tetrahydrofuran (3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane (3S)-3-[4-(2-chloro-5-iodobenzyl)-phenoxy]-tetrahydrofuran Furan, 3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-, (3S)- Empagliflozin Intermediate1 3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (3S-3-(4)Chloro-5-Iodophenyl)Methyl)Phenoxy)Tetrahydro-Furan 1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene Englitin Impurity 28 (3S)-3-{4-[(2-chL ]phenoxy}oxoL oro-5-iodophenyL (3S)-3-[4-[(2-CHLORO-5-IODOPHENYL)METHYL]PHENOXY]TETRAHYDRO-FURAN 915095-94-2 (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan(For export only) (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan ISO 9001：2015 REACH Empagliflozin Impurity 110 (3S)-3-[4-[(5-Iodo-2- Chlorophenyl) Methyl] Phenoxy] Tetrahydrofuran (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-... EMpagliflozin iMpurity C (S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene Empagliflozin Intermediate/ (3S)-3-[4-[(2-Chloro-5-Iodophenyl)Methyl]Phenoxy]Tetrahydro-Furan (3S)-3-[4-4(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc 915095-94-2 C17H16ClIO2 Empagliflozin Empagliflozin Intermediate 915095-94-2