Cinchocain
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- CAS-Nr.
- 85-79-0
- Bezeichnung:
- Cinchocain
- Englisch Name:
- Cinchocaine
- Synonyma:
- Dibucain;percamine;DIBUCAINE;INN / BAN;Dermacaine;Nupercaine;Nupercainal;CINCHOCAINE;Zinn cocaine;DIBUCAINE BASE
- CBNumber:
- CB1396856
- Summenformel:
- C20H29N3O2
- Molgewicht:
- 343.46
- MOL-Datei:
- 85-79-0.mol
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Cinchocain Eigenschaften
- Schmelzpunkt:
- 64°
- Siedepunkt:
- 478.73°C (rough estimate)
- Dichte
- 1.1145 (rough estimate)
- Brechungsindex
- 1.6300 (estimate)
- storage temp.
- Store at -20°C
- Löslichkeit
- DMSO:45.0(Max Conc. mg/mL);131.02(Max Conc. mM)
- pka
- pKa -5.3(aq. H2SO4) (Uncertain)
- Aggregatzustand
- Solid:particulate/powder
- Wasserlöslichkeit
- 68.01mg/L(temperature not stated)
- InChI
- InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)
- InChIKey
- PUFQVTATUTYEAL-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2)C(C(NCCN(CC)CC)=O)=CC=1OCCCC
- LogP
- 4.4 at 25℃ and pH7
- CAS Datenbank
- 85-79-0(CAS DataBase Reference)
- NIST chemische Informationen
- Dibucaine(85-79-0)
Cinchocain Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R41:Gefahr ernster Augenschäden.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
Verwenden
Cinchocaine is a local anesthesic,used for Na
+ channel blocker.
Definition
ChEBI: A monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally o
ly used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.
Allgemeine Beschreibung
Articaine has a secondary nitrogen with a pKa of 7.8. It containsan aromatic thiophene ring bioisostere of the phenylring found in most other amide anesthetics. The log P of abenzene ring is 2.13 and the thiophene ring log P is 1.81,thus the thiophene ring is more hydrophilic than a phenylring. Although the thiophene ring has less lipid solubilitythan a phenyl ring, articaine is a lipid-soluble compound dueto the propylamine, the branched methyl and the substitutionson the thiophene ring. The onset of action of articaineis similar to lidocaine’s onset of action.
Kontakt-Allergie
Dibucaine hydrochloride is an amide group local anesthetic
that can induce allergic contact dermatitis.
Clinical Use
Articaine is availablein a 4% solution with epinephrine for use in infiltrationand nerve block anesthesia.Articaine is metabolized rapidly via plasma and tissuecarboxyesterase to its primary metabolite, the inactive,water-soluble carboxylic acid. Approximately 40% to 70%of articaine administered epidurally is metabolized to thecarboxylic acid, articainic acid. Approximately 4% to 15%of the articainic acid undergoes glucuronide conjugationand only 3% of the dose is recovered unchanged in theurine. The rapid plasma metabolism and reported inactivityof the carboxylic acid metabolite make articaine a potentiallysafer anesthetic agent when multiple or large dosesare necessary.
Cinchocain Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cinchocain Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 178)Lieferanten
85-79-0(Cinchocain)Verwandte Suche:
- 2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamid
- 2-butoxy-n-(2-(diethylamino)ethyl)-cinchoninamid
- 2-butoxy-n-(2-(diethylamino)ethyl)cinchoninamide
- 2-butoxy-n-(2-(diethylamino)ethyl-4-quinolinecarboxamid
- 2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide
- 2-Butoxy-N-[2-(diethylamino)ethyl]cinchoninamide
- 2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide
- 2-butoxyquinoline-4-carboxylicaciddiethylaminoethylamide
- 2-n-butoxy-n-(2-diethylaminoethyl)cinchoninamide
- 4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]-
- alpha-butyloxycinchonicacid-gamma-diethylethylenediamine
- alpha-Butyloxycinchoninic acid diethylethylenediamide
- alpha-butyloxycinchoninicaciddiethylethylenediamide
- Cinchoninamide, 2-butoxy-N-[2-(diethylamino)ethyl]-
- Dermacaine
- Dibucain
- dibucainesolution
- n-(2-(diethylamino)ethyl)-2-butoxycinchoninamide
- N-[2-(Diethylamino)ethyl]-2-butoxycinchoninamide
- Nupercainal
- Nupercaine
- percamine
- dibucaine free base crystalline
- Cinchocaine (Dibucaine)
- Dibucaine(baseand/orunspecifiedsalts)
- Cinchocainebase
- Cinchocaine HCl (base)
- 2-BUTOXY-N-[2-(DIETHYLAMINO)-ETHYL]-4-QUINOLINE CARBOXAMIDE
- 2-BUTOXY-N-[2-(DIETHYLAMINO)ETHYL]CINCHONAMIDE
- 2-butoxy-n-(2-diethylaminoethyl)quinoline-4-carboxamide
- A-BUTOXYCINCHONINIC ACID DIETHYLETHYLENEDIAMIDE
- CINCHOCAINE
- DIBUCAINE
- DIBUCAINE BASE
- Dibucaine（Cinchocaine Dibucaine,Sovcaine,Percaine）
- Cinchocaine - USP
- Chloroprocaine hydrochloride Solution, 100ppm
- 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide hydrochloride, calculated with reference to the dried substance.
- Zinn cocaine
- Cinchocaine USP/EP/BP
- Dibucaine/ocaine Nepocaine
- Dibucaine (Cinchocaine)
- CinchocaineQ: What is
Cinchocaine Q: What is the CAS Number of
Cinchocaine Q: What is the storage condition of
Cinchocaine
- INN / BAN
- 85-79-0
- 61-21-1
- C20H29N3O2
- research chemical
- DIA - DICDrugs of Abuse
- Alphabetic
- Chemical Structure
- D
- Others
- 85-79-0
