COP-1

28704-27-0

CAS-Nr.: 28704-27-0

Englisch Name:: COP-1

Synonyma:: COP-1;Copaxone;poly(ala;(t,g)-a-l;[L-ALA, L-GLU, L-LYS HBR, L-TYR]N;(l-ala, l-glu, l-lys, l-tyr)n ·hbr;POLY(ALA, GLU, LYS, TYR) HYDROBROMIDE;poly(alanine-glutamic acid-lysine-tyrosine);COP-1, (L-Ala, L-Glu, L-Lys, L-Tyr)n HBr;poly(ala, glu, lys, tyr) 6:2:5:1 hydrobromide

CBNumber:: CB2151979

Summenformel:: C23H41N5O11

Molgewicht:: 563.61

MOL-Datei:: 28704-27-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 18

COP-1 Eigenschaften

storage temp.: −20°C

Sicherheit

WGK Germany	3

COP-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Copaxone was launched in Israel and the US for treatment of relapsingremitting multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed by deprotection. Structurally, the random polymer, with a residue molar ratio of 6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it immunomodulating and immunosuppressive activity (antigen specific so not a general immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR) molecules which results both in competition with myelin antigens for T-cell activation and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific interaction gives rise to a reduced probability of long-term damage to the immune system. The competition with MBP and other myelin-associated antigens inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates and is non-species specific. It resulted in a 29% reduction in relapse rate and is most effective in patients with less accumulated neurologic disability.

Originator

Yeda (Israel)

Trademarks

Copaxone

COP-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

COP-1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 18)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Protheragen-ING	+16313385890	info@protheragen-ing.com	United States	1091	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
Nanjing Peptide Biotech Ltd.	025-025-58361106-805-805 13082558573	liugang@njpeptide.com	China	9962	55
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Guangzhou Yunmen Biotechnology Co., Ltd	18902340307 18902340307	3356812514@qq.com	China	9242	58
Nanjing Yuanpeptide Biotech Co.，Ltd.	18168071971	support@yuan-peptide.com	China	2977	58
HUBEI HICKS BIOCHEMICAL CO.,LTD	18696113233	15927219311@163.com	China	1624	58
Hubei Hicks Biochemical Co., Ltd	17362916295; 17362916295	w17362916295@163.com	China	4054	58
Zhejiang Jiekun Biotechnology Co., Ltd	0571-88211951 13735575465	sales1@gotopbio.com	China	4904	58

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[L-ALA, L-GLU, L-LYS HBR, L-TYR]N
COP-1
POLY(ALA, GLU, LYS, TYR) HYDROBROMIDE
(t,g)-a-l
poly(ala
POLY(ALA, GLU, LYS, TYR) 6:2:5:1*HYDROBR OMIDE MOL.
Copaxone
(l-ala, l-glu, l-lys, l-tyr)n ·hbr
poly(ala, glu, lys, tyr) 6:2:5:1 hydrobromide
poly(alanine-glutamic acid-lysine-tyrosine)
COP-1, (L-Ala, L-Glu, L-Lys, L-Tyr)n HBr
Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
28704-27-0
C3H5NOnH2O
Polyamino Acids
Random Copolymers
Biochemicals and Reagents
Amino Acids and Peptides
BioChemical