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(p-Toluolsulfonyl)methylisocyanid Produkt Beschreibung

Tosylmethyl isocyanide Struktur
36635-61-7
CAS-Nr.
36635-61-7
Bezeichnung:
(p-Toluolsulfonyl)methylisocyanid
Englisch Name:
Tosylmethyl isocyanide
Synonyma:
TOSMIC;isocyanide;Tosylmethyl isocyani;LABOTEST-BB LT00159629;TOSYLMETHYL ISOCYANIDE;Tosylmethyleisocyanide;Tosylmethyl isocyanide,98%;Tosylmethy isocyanide ,98%;p-Toluenesulfonyl Isocyanide;TosMIC Tosylmethyl Isocyanide
CBNumber:
CB5311774
Summenformel:
C9H9NO2S
Molgewicht:
195.24
MOL-Datei:
36635-61-7.mol

(p-Toluolsulfonyl)methylisocyanid Eigenschaften

Schmelzpunkt:
109-113 °C(lit.)
Dichte
1.2721 (rough estimate)
Brechungsindex
1.5270 (estimate)
storage temp. 
2-8°C
Löslichkeit
water: slightly soluble
Aggregatzustand
Liquid
Farbe
Clear
Wasserlöslichkeit
insoluble
Sensitive 
Moisture Sensitive
Merck 
14,9556
BRN 
3592382
InChIKey
BBNNLJMGPASZPD-UHFFFAOYSA-N
CAS Datenbank
36635-61-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,Xi
R-Sätze: 23/24/25
S-Sätze: 36/37-45-38-36/37/39-28A
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
21
Hazard Note  Irritant
HazardClass  6.1(b)
PackingGroup  III
HS Code  29299000
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H311 Giftig bei Hautkontakt. Akute Toxizität dermal Kategorie 3 Achtung P280, P302+P352, P312, P322, P361,P363, P405, P501
H331 Giftig bei Einatmen. Akute Toxizität inhalativ Kategorie 3 Achtung P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P309 BEI Exposition oder Unwohlsein:
P310 Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

(p-Toluolsulfonyl)methylisocyanid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S38:Bei unzureichender Belüftung Atemschutzgerät anlegen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

Pale yellow to light brown crystalline powder

Verwenden

Reagent for use in the preparation of biologically active pyrroles and imidazoles.1,2

Verwenden

Tosylmethyl Isocyanide is used as a synthetic reagent in the preparation of variety or biologically active heterocycles such as pyrroles and imidazoles. Tosylmethyl Isocyanide is reported to inhibit [ Fe]-hydrogenase with very high affinity.

Verwenden

Versatile synthon in organic chemistry, especially in the synthesis of heterocyclic Compounds.

synthetische

N-(p-Tolylsulfonylmethyl)formamide 1609:

A 3-L, three-necked, round-bottomed flask, equipped with a mechanical stirrer, a condenser, and a thermometer, was charged with sodium p-toluenesulfinate 1606 (267 g, 1.5 mol). After the addition of water (750 mL), a 34–37% solution of formaldehyde 1607 (350 mL, 378 g, ca. 4.4 mol), formamide 1608 (600 mL, 680 g, 15 mol), and formic acid (200 mL, 244 g, 5.3 mol), the stirred reaction mixture was heated at 90 C°. The sodium p-toluenesulfinate dissolved during the heating, and the clear solution was kept at 90–95 C° for 2 h. It was then cooled in an ice/salt bath with continued stirring and further cooled overnight in a freezer at 20 C°. The white solid produced was collected by suction filtration. It was washed thoroughly in a beaker by stirring with three 250 mL portions of iced water. The product was dried under reduced pressure over phosphorus pentoxide at 70 C° to provide 134–150 g (42–47%) of crude N-(p-tolylsulfonylmethyl)formamide 1609; mp 106–110 C°. This product was sufficiently pure to be used directly in the following reaction.

läuterung methode

Use an efficient fume cupboard. Purify TOSMIC by dissolving (50g) in CH2Cl2 (150mL) and passing it through a column (40x3cm) containing neutral alumina (100g) in CH2Cl2 and eluting with CH2Cl2. A nearly colourless solution (700mL) is collected, evaporated in vacuo and the residue (42-47g) of TOSMIC (m 113-114o dec) is recrystallised once from MeOH (m 116-117o dec). [Hoogenboom et al. Org Synth 57 102 1977, Lensen Tetrahedron Lett 2367 1972.] It also crystallises from EtOH (charcoal) [Saito & Itano, J Chem Soc, Perkin Trans 1 1 1986].

(p-Toluolsulfonyl)methylisocyanid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(p-Toluolsulfonyl)methylisocyanid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 383)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Jinan Carbotang Biotech Co.,Ltd.
+86 15866703830
figo.gao@foxmail.com CHINA 2778 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5873 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Chengdu Feibo Pharm Technology Co., Ltd
15982321820
abby@arkpharm.com CHINA 3281 58

36635-61-7((p-Toluolsulfonyl)methylisocyanid)Verwandte Suche:


  • 1-[(isocyanomethyl)sulfonyl]-4-methyl-benzen
  • Tosylmethy isocyanide ,98%
  • Tosylmethyl isocyani
  • Isocyanomethyl 4-methylphenyl sulphone
  • Toluenesulfonyl Methyl isocyanide
  • 4-[(Isocyanomethyl)sulphonyl]toluene, (Toluene-4-sulphonyl)methyl isocyanide
  • (p-Toluensulfonyl)methylisocyanide
  • (p-Tolylsulfonyl)methyl isocyanide, TosMIC, Tosylmethyl isocyanide
  • (4-Methylphenylsulfonylmethyl) isocyanide
  • 4-Methylphenylsulfonylmethyl isocyanide
  • Tosylmethyl isocyanide,98%
  • p-Toluenesulfonyl Isocyanide
  • P-tolysulfonylmethylisocyanide
  • TosylMethyl isocyanide, 98% 25GR
  • TosylMethyl isocyanide, 98% 5GR
  • 4-TolylsulfonylMethyl Isocyanide
  • IsocyanoMethyl p-Tolyl Sulfone
  • TosMIC Tosylmethyl Isocyanide
  • p-ToluenesulonylMethy isocyanide
  • 4-[(Isocyanomethyl)sulphonyl]toluene, (Toluene-4-sulphonyl)methyl isocyanide, TosMIC
  • TosylMethyl Isocyanide, TOSMIC
  • 4-TOLUENESULFONYLMETHYL ISOCYANIDE FOR S
  • METHYLIDYNE[[(4-METHYLPHENYL)SULFONYL]METHYL]AMMONIUM
  • LABOTEST-BB LT00159629
  • BENZENE, 1-[(ISOCYANOMETHYL)SULFONYL]-4-METHYL-
  • 1-[(ISOCYANOMETHYL)SULFONYL]-4-METHYLBENZENE
  • 4-TOLUENSULFONYLMETHYL ISOCYANIDE
  • 4-TOLUENESULPHONYLMETHYL ISOCYANIDE
  • 4-TOLUENESULFONYLMETHYL ISOCYANIDE
  • P-TOLUENESULFONYLMETHYL ISOCYANIDE
  • P-TOLUENESULPHONYLMETHYL ISOCYANIDE
  • (P-TOLYLSULFONYL)METHYL ISOCYANIDE
  • TOSYLMETHYL ISOCYANIDE
  • TOSMIC
  • TOLUENE-4-SULFONYLMETHYL ISOCYANIDE
  • 4-Toluenesulfonylmethyl isocyanate
  • p-Toluenesulfonylmethyl isocyanide, 98+%
  • p-Toluenesulfonylmethylisocyanide,97+%
  • 1-ISOCYANOMETHANESULFONYL-4-METHYL-BENZENE
  • p-toluenesulfonylmethyl isocyande
  • p-Toluenesulfonylmethyl isocyanate
  • P-TOLUENESULFONYLMETHYL ISOCYANIDE 98%
  • p-ToluenesulfonylMethyl isocyanide, 98.5%
  • p-Toluenesulfonylmethyl Isocyanide
  • 4-Toluenesulfonylmethyl isocyanide for synthesis
  • Tosylmethyleisocyanide
  • 1-[(ISOCYANOMETHYL)SULFONYL]-
  • isocyanide
  • Tosylmethyl isocyanide, 98%, for synthesis
  • Tosylmethyl isocyanide fandachem
  • Tosylmethyl isocyanide ISO 9001:2015 REACH
  • 36635-61-7
  • CH3C6H4SO2CH2NC
  • Organic Building Blocks
  • Isocyanides
  • Nitrogen Compounds
  • Sulfur Compounds (for Synthesis)
  • Building Blocks
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