6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on

DIACYLGLYCEROL KINASE INHIBITOR I Struktur

93076-89-2

CAS-Nr.: 93076-89-2

Bezeichnung:: 6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on

Englisch Name:: DIACYLGLYCEROL KINASE INHIBITOR I

Synonyma:: DKI;DAGK;DGKE;DGKI;DAGK4;DAGK7;DGK-θ;R59022;DKGI-I;DAG KINASE

CBNumber:: CB3335279

Summenformel:: C27H26FN3OS

Molgewicht:: 459.58

MOL-Datei:: 93076-89-2.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 66

6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on Eigenschaften

Siedepunkt:: 619.8±65.0 °C(Predicted)

Dichte: 1.26±0.1 g/cm3(Predicted)

storage temp.: -20°C

Löslichkeit: 0.1 M HCl: slightly soluble

Aggregatzustand: solid

pka: 7.76±0.20(Predicted)

Farbe: pale yellow

Stabilität:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

S-Sätze:	23-24/25
WGK Germany	3

6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

R-59-022 acts as an inducer of apoptosis in glioblastoma cells and avoids apoptosis in non-cancerous cells. This selectivity makes this drug a highly effective anti-cancer agent. Diacylglycerol Kinase inhibitor.

Biologische Aktivität

Diacylglycerol (DAG) kinase inhibitor (IC 50 = 2.8 μ M); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.

6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 66)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58

93076-89-2(6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on)Verwandte Suche:

Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium (Ethylenbis(nitrilomethylidyn)-2,2'-diphenolato)cobalt(II) Dichloro(ethylendiamin)platin 2-Methylpropylisocyanid Kupfer(II)-4-oxopent-2-en-2-olat Methylisocyanacetat Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium Aluminiumtris(2,4-pentandionato-O,O') Benzylisocyanid N-Butylisocyanid (Pentan-2,4-dionato-O,O')silber Ethylisocyanacetat Phenylselenol 1,1,3,3-Tetramethylbutylisocyanat (p-Toluolsulfonyl)methylisocyanid 6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on Tris(pentan-2,4-dionato)eisen(II)

DIACYLGLYCEROL KINASE
DIACYLGLYCEROL KINASE INHIBITOR I
DIACYLGLYCEROL KINASE INHIBITOR I (R59 022)
DAGK
DAG KINASE
EC 2.7.1.107
EC: 2.7.1.107
DKI
SN-1,2-DIACYLGLYCEROL KINASE
SN-1,2-DIACYLGLYCEROL KINASE, RECOMBINANT, E COLI
R59022
DIACYLGLYCEROL KINASE FROM E. COLI
6-[2-[4-[(4-fluorophenyl)phenylmethylene]-1-piperidin-yl]ethyl]-7-methyl-5h-thiazolo-[3,2-a]-pyrimidin-5-one
DIACYLGLYCEROL KINASE SOLUTION
R59022, 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one
Diacylglycerol Kinase from Escherichia coli
sn-1,2-Diacylglycerol kinase, DAGK
5H-Thiazolo(3,2-A)pyrimidin-5-one, 6-(2-(4-((4-fluorophenyl)phenylmethylene)-1-piperidinyl)ethyl)-7-methyl-
6-(2-(4-((4-Fluorophenyl)phenylmethylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo(3,2-A)pyrimidine-5-one
6-[2-[4-[(4-Fluorophenyl)phenylMethylene]-1-piperidin-yl]ethyl]-7-Methyl-5H-thiazolo-[3,2-a]-pyriMidin-5-one, R59022
DGKE
Anti-DGKQ, C-Terminal antibody produced in rabbit
DAGK4
DAGK7
DGK-θ
Anti-DGKI, C-Terminal antibody produced in rabbit
DGKI
Diglyceride kinase κ
Anti-DGKD, N-Terminal antibody produced in rabbit
6-[2-[4-[(P-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO(3,2-A)PYRIMIDINE-5-ONE
6-[2-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL)ETHYL]-7-METHYL-5H-THIAZOLO-[3,2-A]-PYRIMIDIN-5-ONE
6-[2-[4-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE
6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem
DKGI-I
R 59022,R 59 022
93076-89-2
Diacylglycerol kinase (DAGK)
Enzymes, Inhibitors, and Substrates
Signal Transduction
Serine/Threonine Kinase Inhibitors
Kinase/Phosphatase Biology
Cell Biology
Cell Signaling and Neuroscience
Cell Signaling Enzymes
Application Index
Biochemicals and Reagents
BioChemical
Lipid signaling