H-8 DIHYDROCHLORIDE

113276-94-1

CAS-Nr.: 113276-94-1

Englisch Name:: H-8 DIHYDROCHLORIDE

Synonyma:: H-8;H-8 HYDROCHLORIDE;H-8 DIHYDROCHLORIDE;H-8 dihydrochloride,98%;H8, dihydrochloride salt;H-8 dihydrochloride >98% (HPLC);H8 (hydrochloride),H 8 (hydrochloride);H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C;N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide;2-(5-isoquinolinylsulfonylamino)ethyl-methylammonium

CBNumber:: CB3341825

Summenformel:: C12H17Cl2N3O2S

Molgewicht:: 338.25

MOL-Datei:: 113276-94-1.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 72

H-8 DIHYDROCHLORIDE Eigenschaften

Schmelzpunkt:: 221-222℃ (methanol water )

storage temp.: 2-8°C

Löslichkeit: ethanol: 25 mg/mL, clear, colorless

Aggregatzustand: Lyophilized

Farbe: White to Off-White

CAS Datenbank: 113276-94-1(CAS DataBase Reference)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
HS Code	29334990

H-8 DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with K_i values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC₅₀ values of 47 and 6.2 μM, respectively.

Chemische Eigenschaften

white to off-white crystalline solid

Verwenden

Active inhibitor of cyclic-nucleotide-dependent protein kinases.

H-8 DIHYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

H-8 DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 72)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006608290; 18621169109	market03@meryer.com	China	40241	62
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50

113276-94-1()Verwandte Suche:

1,4-Phenylendiamin-dihydrochlorid 10-(3-(4-Methyl-1-piperazinyl)-propyl)-2-(trifluor-methyl)-10H-dihydrochlorid 1-(m-Tolyl)piperazindihydrochlorid 1,3-Propandiamindihydrochlorid 1-(3-Methoxyphenyl)piperazindihydrochlorid Tetramethylendiammoniumdichlorid 1-[3-(Trifluormethyl)phenyl]piperaziniumchlorid 1,4'-Bipiperidindihydrochlorid 1,3-Phenylendiamin-dihydrochlorid (Tetrahydro-1H-1,4-diazepin-1,4(5H)-diyl)di(propan-1,3-diyl)bis(3,4,5-trimethoxybenzoat)dihydrochlorid

5-IsoquinolinesulfonaMide,N-[2-(MethylaMino)ethyl]-, hydrochloride (1:2)
H-8 DIHYDROCHLORIDE
H-8 HYDROCHLORIDE
H-8
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, DI-HCL SALT
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE
N-(2-[METHYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE-5-SULFONAMIDE DIHYDROCHLORIDE
H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C
H-8 dihydrochloride,98%
N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
H8, dihydrochloride salt
2-(5-isoquinolinylsulfonylamino)ethyl-methylammonium
H-8 dihydrochloride >98% (HPLC)
H8 (hydrochloride),H 8 (hydrochloride)
113276-94-1
C12H15N3O2S2HCl