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Hydroxylamin Produkt Beschreibung

HYDROXYLAMINE Struktur
7803-49-8
CAS-Nr.
7803-49-8
Bezeichnung:
Hydroxylamin
Englisch Name:
HYDROXYLAMINE
Synonyma:
NH2OH;FH-50;FH-50TM;Oxyammonia;Oxammonium;Hydroxyamine;azinous acid;HYDROXYLAMINE;HYDROXYLAMINE Joyce;hydroxylaminefree-base
CBNumber:
CB3345090
Summenformel:
H3NO
Molgewicht:
33.03
MOL-Datei:
7803-49-8.mol

Hydroxylamin Eigenschaften

Schmelzpunkt:
7°C
Siedepunkt:
>100 °C
Dichte
1.078 g/mL at 25 °C
Dampfdruck
9 mm Hg ( 40 °C)
Brechungsindex
n20/D 1.393
RTECS-Nr.
NC2975000
storage temp. 
Store below +30°C.
Aggregatzustand
white flakes or needles
pka
pK (20°) 7.97
Wasserlöslichkeit
Miscible with water, liquid ammonia and methanol. Slightly miscible with ether, benzene, carbon disulfide and chloroform.
Merck 
13,4853
Stabilität:
Stable. Incompatible with oxidizing agents, potassium dichromate, chromium trioxide, zinc, calcium, copper, sodium, ammonia, carbonyls, phosphorus halides, pyridine, hypochlorites.
InChIKey
AVXURJPOCDRRFD-UHFFFAOYSA-N
CAS Datenbank
7803-49-8(CAS DataBase Reference)
NIST chemische Informationen
Hydroxylamine(7803-49-8)
EPA chemische Informationen
Hydroxylamine (7803-49-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,N
R-Sätze: 5-22-37/38-41-43-48/22-50-40-21/22
S-Sätze: 23-26-36/37/39-47-61-22-46
RIDADR  UN 3082 9/PG 3
WGK Germany  3
4.8
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  28251090
Giftige Stoffe Daten 7803-49-8(Hazardous Substances Data)
Toxizität LD50 i.p. in mice: 1.83 mmol/kg (Smith, Layne)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H290 Kann gegenüber Metallen korrosiv sein. Korrosiv gegenüber Metallen Kategorie 1 Warnung P234, P390, P404
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H313 Kann bei Hautkontakt gesundheitsschädlich sein. Acute toxicity,dermal Category 5 P312
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Verursacht schwere Augenschäden. Schwere Augenschädigung Kategorie 1 Achtung P280, P305+P351+P338, P310
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H371 Kann die Organe schädigen. Spezifische Zielorgan-Toxizität Kategorie 2 Warnung P260, P264, P270, P309+P311, P405,P501
H373 Kann die Organe schädigen bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P261 Einatmen von Staub vermeiden.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Hydroxylamin Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

STARK HYGROSKOPISCHE WEISSE NADELN ODER FLOCKEN.

ARBEITSPLATZGRENZWERTE

TLV nicht festgelegt (ACGIH 2005).
MAK: Sensibilisierung der Haut; (DFG 2005).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

INHALATIONSGEFAHREN

Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.

WIRKUNGEN BEI KURZZEITEXPOSITION

WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Haut und die Atemwege und verätzt die Augen. Möglich sind Auswirkungen auf das Blut mit nachfolgender Methämoglobinbildung. Die Auswirkungen treten u.U. verzögert ein. ärztliche Beobachtung notwendig.

WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen. Möglich sind Auswirkungen auf das Blut mit nachfolgender Methämoglobinbildung und Blutarmut.

LECKAGE

Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.

R-Sätze Betriebsanweisung:

R5:Beim Erwärmen explosionsfähig.
R22:Gesundheitsschädlich beim Verschlucken.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augenschäden.
R43:Sensibilisierung durch Hautkontakt möglich.
R48/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
R50:Sehr giftig für Wasserorganismen.

S-Sätze Betriebsanweisung:

S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S47:Nicht bei Temperaturen über . . . °C aufbewahren (vom Hersteller anzugeben).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S22:Staub nicht einatmen.

Beschreibung

Hydroxylamine was first synthesized by Wilhem Clemens Lossen in 1865 in the laboratory of Wilhelm Heinrich Heintz while working in Halle. The Lossen synthesis originally generated hydroxylamine in aqueous solution. Anhydrous hydroxylamine was prepared later by Lobry de Bruyn and Crismer in 1891. The free base is extremely volatile, and industrial-scale production has been fraught with problems, including large explosions at facilities in the United States and Japan. Much of the hydroxylamine produced and transported is in salt form or as a dilute aqueous solution.

Chemische Eigenschaften

slightly yellow liquid

Physikalische Eigenschaften

White crystalline solid; orthogonal plates or needles; unstable; density 1.21g/cm3at 20°C; melts at 33°C; vaporizes at 58°C; very soluble in water, liquidammonia and lower alcohols; sparingly soluble in most other organic solvents;decomposes in hot water; pKa5.94 at 25°C.

Verwenden

Reducing agent used in photographic processing, leather tanning, manufacturing of nylon and other polymers; as a stabilizer for natural rubber; to prevent the development of objectionable tastes and odors during the refining of fatty materials.

Verwenden

Hydroxylamine is used as a reducing agent in photography, in synthetic and analytical chemistry, as an antioxidant for fatty acids and soaps, and as a dehairing agent for hides. In addition, hydroxylamine is used in the production of cyclohexanone oxime, an isomer of caprolactam, which is an intermediate in the production of nylon-6. In the semiconductor industry, hydroxylamine can be a component of a solution that dissolves a photoresist following lithography. Hydroxylamine can also be used to selectively cleave asparaginyl-glycine peptide bonds.

Verwenden

Reducing agent, organic synthesis.

Definition

ChEBI: The simplest hydroxylamine, consisting of ammonia bearing a hydroxy substituent. It is an intermediate in the biological nitrification by microbes like bacteria.

synthetische

Hydroxylamine is unstable as a free base. It is prepared from hydroxy-lamine hydrochloride, NH2OH?HCl, which is obtained by electrolytic reduc-tion of ammonium chloride solution. The hydrochloride undergoes alkalinedecomposition to hydroxylamine, which is collected by vacuum distillation.

Definition

hydroxylamine: A colourless solid,NH2OH, m.p. 33°C. It explodes onheating and may be employed as anoxidizing agent or reducing agent. Itis made by the reduction of nitratesor nitrites, and is used in makingnylon. With aldehydes and ketones itforms oximes.

Allgemeine Beschreibung

Odorless white crystalline solid. Sinks and mixes with water.

Air & Water Reaktionen

Decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. Reacts with water or steam to produce heat and corrosive liquids.

Reaktivität anzeigen

HYDROXYLAMINE is a white solid, thermally unstable, decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. HYDROXYLAMINE should be stored below 10° C [Bailar, 1973, vol. 2, p. 272]. Explosive reaction with strong oxidizers (chromium trioxide, potassium dichromate) or powdered zinc upon heat. Reaction with zinc or calcium produces explosive bishydroxylamides. HYDROXYLAMINE ignites on contact with cupric sulfate, alkali metals (sodium, potassium), oxidants (e.g., barium oxide, barium peroxide, lead dioxide, potassium permanganate, chlorine), phosphorus trichloride and pentachloride. HYDROXYLAMINE reacts vigorously with hypochlorites, pyridine, carbonyls [Sax, 9th ed., 1996, p. 1875]. On contact with organic materials in thin layer (e.g., crystals on filter paper), HYDROXYLAMINE may ignite spontaneously in air. HYDROXYLAMINE explodes when heated above 70° C [Brauer, 1963, vol. 1, p. 502]. During a distillation process, an explosion occurred. Potassium hydroxide is thought to be involved in the explosion. Employees in the plant complained of chest pains and suffered chemical burns. Five people were killed by the explosion.

Hazard

Decomposes rapidly at room temperature, violently when heated, detonates in flame-heated test tube. Irritant to tissue.

Health Hazard

INHALATION: Moderately toxic by inhalation and oral routes with the following symptoms possible: headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported. EYES: Corrosive - highly irritating. SKIN: Irritating or corrosive to skin. INGESTION: Moderately toxic by inhalation and oral routes with the following symptoms possible; headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported.

Kontakt-Allergie

Hydroxylamine and its salts are used in various branches of industry, as reducing agents in color film developers or as reagents in laboratories.

Carcinogenicity

Carcinogenicity of hydroxylamine and its salts has not been demonstrated. Several studies have shown a decreased incidence of spontaneous mammary tumors in mice exposed to the sulfate and hydrochloride.3–7 There was some indication of an increase in the incidence of spontaneous mammary tumors when the sulfate was administered to older animals whose mammary glands were already well developed.

Environmental Fate

The large-scale production and use of hydroxylamine may result in its release to the environment through various waste streams. Hydroxylamine will exist solely as a vapor in the ambient atmosphere, and will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 h.
Abiotic degradation of hydroxylamine by photochemically produced peroxy radicals is an important environmental fate process in surface waters, with the half-life of the reaction measured at approximately 2 h. An estimated bioconcentration factor of 3 suggests that the potential for bioconcentration in aquatic organisms is low. If released terrestrially, hydroxylamine will most likely exist in its protonated form due to its pKa of 5.94; the protonated form is nonvolatile. Koc estimates of 14 for hydroxylamine suggest that it may have very high mobility in soil.

läuterung methode

Crystallise it from n-butanol at -10o, collect it by vacuum filtration and wash it with cold diethyl ether. Harmful vapours. [Hurd Inorg Synth I 87 1939, Semon in Org Synth Coll Vol I 318 1932.]

Toxicity evaluation

Hydroxylamine acts as a reducing agent when absorbed systemically, producing methemoglobin and the formulation of Heinz bodies in the blood. It can induce hemolytic anemia. It inhibits platelet aggregation and is a nitric oxide vasodilator. Oxylamines such as hydroxylamine and methoxylamine disturb DNA replication and act as potent mutagens, causing nucleotide transition from one purine to another or one pyrimidine to another.
Allergic reactions of the skin following dermal exposure to hydroxylamine resemble contact eczema, or possibly urticaria of Quincke’s edema. The pathogenesis of this reaction appears to be mediated by a delayed type T-lymphocyte reaction.

Hydroxylamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Hydroxylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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Hubei Jusheng Technology Co.,Ltd.
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7803-49-8(Hydroxylamin)Verwandte Suche:


  • hydroxylamine,freebase
  • hydroxylaminefree-base
  • NH2OH
  • Oxammonium
  • Oxyammonia
  • FH-50
  • FH-50TM
  • HYDROXYLAMINE
  • Hydroxylamine solution
  • HYDROXYLAMINE, 50 WT. % SOLUTION IN WATE R
  • HYDROXYLAMINE, 99.999%, 50 WT. SOLUTION IN WATER
  • HYDROXYLAMINE SOLUTION, ~50% IN WATER
  • Hydroxylamine, 50% aq. soln.
  • HYDROXYLAMINE: 50% AQUEOUS SOLUTION
  • Hydroxyamine
  • HydroxylaMine solution 50 wt. % in H2O
  • HYDROXYLAMINE,FREEBASE,50%AQUEOUSSOLUTION
  • azinous acid
  • Hydroxylamine, 50 wt% aq. soln.
  • HYDROXYLAMINE Joyce
  • hydroxylamine,freebase HYDROXYLAMINE Hydroxylamine solution
  • HydroxylaMine solution 50 wt. % in H2O, 99.999%
  • HydroxylaMine in Methanol
  • Hydroxylamine (50% in Water)
  • Hydroxylamine solution, 50 wt. % in water
  • 50% Hydroxylamine Solution
  • Hydroxylamine, 50wt.% in H2O
  • 7803-49-8
  • H3ON
  • H2NOH
  • Others
  • Synthetic Reagents
  • C-X Bond Formation (Non-Halogen)
  • Pharmaceutical Intermediates
  • C-X Bond Formation (Non-Halogen)
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