(-)-QUINPIROLE HYDROCHLORIDE

(-)-QUINPIROLE HYDROCHLORIDE Struktur
85798-08-9
CAS-Nr.
85798-08-9
Englisch Name:
(-)-QUINPIROLE HYDROCHLORIDE
Synonyma:
LY-171,555;()-Quinpirole;(-)-LY 171555;(4ar-trans)-lorid;(-)-QUINPIROLE HCL;(-)-Quinpirole HCl;(-)-QUINPIROLE HYDROCHLORIDE;(-)-QUINPIROLE HYDROCHLORIDE;(-)-quinpirole monohydrochloride;(-)-QUINPIROLE HYDROCHLORIDE (LY-171555) SELECTIVE D2 DOPAMINE
CBNumber:
CB4687090
Summenformel:
C13H22ClN3
Molgewicht:
255.79
MOL-Datei:
85798-08-9.mol

(-)-QUINPIROLE HYDROCHLORIDE Eigenschaften

storage temp. 
-20°C
Löslichkeit
0.1 M HCl: soluble23mg/mL
Aggregatzustand
solid
Farbe
white
Optische Aktivität
[α]25/D 124.5°, c = 0.4 in H2O(lit.)
Stabilität:
Hygroscopic

Sicherheit

WGK Germany  3
RTECS-Nr. UR0809270

(-)-QUINPIROLE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(-)-Quinpirole hydrochloride has been used as a selective D2 dopamine (DA) receptor agonist in various experiments.

Biochem/physiol Actions

Quinpirole is a dopamine agonist with high affinity for the D2 and D3 dopamine receptor subtypes. Specific [3H]quinpirole binding in rat brain was saturable, and dependent on temperature, membrane concentration, sodium concentration and guanine nucleotides. The putative D2 dopamine receptor agonist quinpirole (LY 171,555) is the most widely used D2 agonist in in vivo and in vitro studies. Quinpirole hydrochloride is an active enantiomer of (±)-quinpirole.Saturation analysis revealed high affinity binding characteristics (KD = 2.3 +/- 0.3 nM) which were confirmed by association-dissociation kinetics. The regional distribution of [3H]quinpirole binding sites roughly paralleled the distribution of [3H]spiperone binding sites, with greatest densities present in the striatum, nucleus accumbens and olfactory tubercles. A variety of drugs, most notably monoamine oxidase inhibitors (MAOls), inhibit the binding of [3H]quinpirole, but not [3H]spiperone or [3H](-)N-n-Propylnorapomorphine, in rat striatal membranes by a mechanism that does not appear to involve the enzymatic activity of MAO. Clinically antidepressant MAOIs exhibited selectivity between sites labeled by [3H]quinpirole and [3H]spiperone as did a number of structurally related propargylamines and N-acylethylenediamine derivatives and other drugs such as debrisoquin and phenylbiguanide. The MAOIs clorgyline and Ro 41-1049 were the most potent. MAOIs interact with a novel binding site that is labeled by [3H]quinpirole or that modulates [3H]quinpirole binding. This site may be associated with D2-like dopamine receptors.

(-)-QUINPIROLE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(-)-QUINPIROLE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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85798-08-9()Verwandte Suche:


  • (4AR-TRANS)-4,4A,5,6,7,8,8A,9-OCTAHYDRO-5-PROPYL-1H-PYRAZOLO[3,4-G]QUINOLINE HYDROCHLORIDE
  • (-)-QUINPIROLE HCL
  • (-)-QUINPIROLE HYDROCHLORIDE
  • TRANS-(-)-4AR-4,4A,5,6,7,8,8A,9-OCTAHYDRO-5-PROPYL-1H-PYRAZOLO[3,4-G] QUINOLINE HYDROCHLORIDE
  • (4ar-trans)-lorid
  • 4-g)quinolone,4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1h-pyrazolo(monohydroch
  • (-)-QUINPIROLE HYDROCHLORIDE (LY-171555) SELECTIVE D2 DOPAMINE
  • (-)-quinpirole monohydrochloride
  • trans-(–)-(4aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline monohydrochloride
  • LY-171,555
  • (4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline:hydrochloride
  • ()-Quinpirole
  • (-)-LY 171555
  • (-)-QUINPIROLE HYDROCHLORIDE
  • (-)-Quinpirole HCl
  • 1H-Pyrazolo[3,4-g]quinoline,4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, hydrochloride (1:1), (4aR,8aR)-
  • (4AR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline hydrochloride
  • 85798-08-9
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