(-)-QUINPIROLE HYDROCHLORIDE

(-)-QUINPIROLE HYDROCHLORIDE 구조식 이미지
카스 번호:
85798-08-9
상품명:
(-)-QUINPIROLE HYDROCHLORIDE
동의어(영문):
LY-171,555;()-Quinpirole;(-)-LY 171555;(4ar-trans)-lorid;(-)-QUINPIROLE HCL;(-)-Quinpirole HCl;(-)-QUINPIROLE HYDROCHLORIDE;(-)-QUINPIROLE HYDROCHLORIDE;(-)-quinpirole monohydrochloride;(-)-QUINPIROLE HYDROCHLORIDE (LY-171555) SELECTIVE D2 DOPAMINE
CBNumber:
CB4687090
분자식:
C13H22ClN3
포뮬러 무게:
255.79
MOL 파일:
85798-08-9.mol
MSDS 파일:
SDS

(-)-QUINPIROLE HYDROCHLORIDE 속성

저장 조건
-20°C
용해도
0.1M HCl: 가용성23mg/mL
물리적 상태
고체
물리적 상태
단단한 모양
색상
하얀색
optical activity
[α]25/D 124.5°, c = 0.4 in H2O(lit.)
안정성
흡습성

안전

WGK 독일 3
RTECS 번호 UR0809270

(-)-QUINPIROLE HYDROCHLORIDE C화학적 특성, 용도, 생산

용도

(-)-Quinpirole hydrochloride has been used as a selective D2 dopamine (DA) receptor agonist in various experiments.

Biochem/physiol Actions

Quinpirole is a dopamine agonist with high affinity for the D2 and D3 dopamine receptor subtypes. Specific [3H]quinpirole binding in rat brain was saturable, and dependent on temperature, membrane concentration, sodium concentration and guanine nucleotides. The putative D2 dopamine receptor agonist quinpirole (LY 171,555) is the most widely used D2 agonist in in vivo and in vitro studies. Quinpirole hydrochloride is an active enantiomer of (±)-quinpirole.Saturation analysis revealed high affinity binding characteristics (KD = 2.3 +/- 0.3 nM) which were confirmed by association-dissociation kinetics. The regional distribution of [3H]quinpirole binding sites roughly paralleled the distribution of [3H]spiperone binding sites, with greatest densities present in the striatum, nucleus accumbens and olfactory tubercles. A variety of drugs, most notably monoamine oxidase inhibitors (MAOls), inhibit the binding of [3H]quinpirole, but not [3H]spiperone or [3H](-)N-n-Propylnorapomorphine, in rat striatal membranes by a mechanism that does not appear to involve the enzymatic activity of MAO. Clinically antidepressant MAOIs exhibited selectivity between sites labeled by [3H]quinpirole and [3H]spiperone as did a number of structurally related propargylamines and N-acylethylenediamine derivatives and other drugs such as debrisoquin and phenylbiguanide. The MAOIs clorgyline and Ro 41-1049 were the most potent. MAOIs interact with a novel binding site that is labeled by [3H]quinpirole or that modulates [3H]quinpirole binding. This site may be associated with D2-like dopamine receptors.

(-)-QUINPIROLE HYDROCHLORIDE 준비 용품 및 원자재

원자재

준비 용품


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